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NEUROLOGY 2006;67:1053-1055
© 2006 American Academy of Neurology
Brief Communications

Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa

R. M. Sugg, MD, N. R. Gonzales, MD, D. E. Matherne, MSN, FNP, M. Ribo, MD, H. M. Shaltoni, MD, S. Baraniuk, E. A. Noser, MD and J. C. Grotta, MD

From the Department of Neurology (R.M.S., N.R.G., D.E.M., M.R., H.M.S., E.A.N., J.C.G.), University of Texas Houston Medical School; and Coordinating Center (S.B.), University of Texas School of Public Health.

Address correspondence and reprint requests to Dr. James C. Grotta, Director of the Stoke Department, Department of Neurology, The University of Houston–Texas, 6431 Fannin–MSB 7.128, Houston, TX 77030; e-mail: james.c.grotta{at}uth.tmc.edu

We report myocardial injury in 20 recombinant factor VIIa (rFVIIa) treated and 110 nontreated patients with intracerebral hemorrhage. Patients were treated or received standard medical management. All received EKG and cardiac enzyme testing. Elevated troponin occurred in 20% treated vs 3% nontreated (p = 0.02). Myocardial infarction occurred in 10% vs 1% (p = 0.01). We found a significant increase in myocardial injury in rFVIIa treated patients.

Editorial, see page 934

See also page 1096

R.M.S., M.R., and N.R.G. were supported by NIH training grant #T32NSO7412 to the University of Texas Houston Medical School Stroke Program.

Disclosure: The authors report no conflicts of interest.

Received February 15, 2006. Accepted in final form July 11, 2006.


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Correspondence:

Read all Correspondence

Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa
Stephan A Mayer, et al.
Neurology Online, 26 Dec 2006 [Full text]
Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa
Salvador Cruz-Flores
Neurology Online, 26 Dec 2006 [Full text]
Reply from the Authors
Rebecca M Sugg, et al.
Neurology Online, 26 Dec 2006 [Full text]