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NEUROLOGY 2006;67:1056-1058
© 2006 American Academy of Neurology


Brief Communications

Changes of brachial flow-mediated vasodilation in different ischemic stroke subtypes

P. L. Chen, MD, P. Y. Wang, MD, W. H. Sheu, PhD, Y. T. Chen, MD, Y. P. Ho, BS, H. H. Hu, MD and H. Y. Hsu, PhD

From the Section of Neurology (P.L.C., P.Y.W., Y.P.H., H.Y.H.), Section of Metabolism and Endocrinology (W.H.S.), and Section of Cardiology (Y.T.C.), Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, R.O.C.; School of Medicine, National Yang-Ming University, Taipei, and Chung-Shan University, Taichung, Taiwan, R.O.C. (P.L.C., P.Y.W., W.H.S., Y.T.C., H.H.H., H.Y.H.); and Institute of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C. (H.H.H.).

Address correspondence and reprint requests to Dr. Hung-Yi Hsu, Section of Neurology, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Sec. 3, Taichung-Kang Rd., Taichung 407, Taiwan, R.O.C.; e-mail: 2941{at}vghtc.gov.tw

The relationship between endothelial dysfunction and stroke subtypes is unclear. We prospectively measured brachial flow-mediated vasodilation (FMD) in 143 patients with acute ischemic stroke and 40 controls. The overall stroke patients had impaired FMD, but only lacunar infarction had significantly impaired FMD vs the controls. Impaired FMD was an independent predictor for lacunar infarction. Ischemic stroke is associated with endothelial dysfunction, which is more conspicuous in lacunar infarction.


This study was supported in part by grants from the Taichung Veterans General Hospital Research Program (TCVGH-940104C and TCVGH-943403B), Taichung, Taiwan.

Disclosure: The authors report no conflicts of interest.

Received October 24, 2005. Accepted in final form May 24, 2006.




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J. M. Wardlaw, A. Farrall, P. A. Armitage, T. Carpenter, F. Chappell, F. Doubal, D. Chowdhury, V. Cvoro, and M. S. Dennis
Changes in Background Blood-Brain Barrier Integrity Between Lacunar and Cortical Ischemic Stroke Subtypes
Stroke, April 1, 2008; 39(4): 1327 - 1332.
[Abstract] [Full Text] [PDF]




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