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Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct

From the Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (K.I., J.H., T.M.); and Division of Neurology, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linköping University, Linköping, Sweden (A.-M.L.).

Address correspondence and reprint requests to Kerstin Imrell, Department of Neurology, R54, Karolinska University Hospital at Huddinge, SE-141 86 Stockholm, Sweden; e-mail: kerstin.imrell{at}ki.se

We sought to determine whether Swedish patients with multiple sclerosis (MS) with and without oligoclonal bands (OCBs) in the CSF constitute distinct subpopulations, clinically and immunogenetically. Our findings indicate that OCB-negative MS shares the same clinical features as OCB-positive MS regarding female predominance, age at onset, proportion of primary progressive cases, rate of MRI positivity, and disease severity. Our HLA-DRB1 genotyping results suggest, however, that OCB-positive and OCB-negative MS are immunogenetically distinct.

Supported by grants from the Swedish Research Council (project number 11220), the Swedish Brain Foundation, the Swedish Association of Neurologically Disabled, the Swedish Society of Medicine, Karolinska Institutet, and the Bibbi and Nils Jensen Foundation.

Disclosure: The authors report no conflicts of interest.

Received January 12, 2006. Accepted in final form June 1, 2006.

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