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NEUROLOGY 2006;67:1086-1087
© 2006 American Academy of Neurology
Brief Communications

Movement-related cortical activation in familial Parkinson disease

A. Delval, MD, L. Defebvre, PhD, E. Labyt, PhD, X. Douay, PhD, J. -L. Bourriez, PhD, N. Waucquiez, MD, P. Derambure, PhD and A. Destée, PhD

From the Department of Clinical Neurophysiology (A.D., E.L., J.-L.B., P.D.) and Department of Neurology and Movement Disorders (A.D., L.D., X.D., N.W., A.D.), Hospital R. Salengro, Regional University Hospital, Lille, France; and EA 2683, MENRT Neurosciences Department IFR 114 (A.D., L.D., E.L., X.D., J.-L.B., N.W., P.D., A.D.), Ministère de l'éducation nationale de la recherche et de la technologie.

Address correspondence and reprint requests to Dr. Luc Defebvre, Service de Neurologie et Pathologie du Mouvement, Hôpital Salengro, F-59037 Lille cedex, France; e-mail: ldefebvre{at}chru-lille.fr.

We sought to determine whether or not first-degree relatives of patients with familial Parkinson disease (FDRs) present impaired movement-related cortical activity. We studied 10 familial Parkinson disease subjects, 10 FDRs, and 10 controls and analyzed event-related mu desynchronization (ERD) and beta synchronization. Forty percent FDRs presented reduced premovement mu ERD latency, suggesting that premovement cortical activation is impaired in FDRs.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the September 26 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received October 17, 2005. Accepted in final form May 23, 2006.






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