HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wishart, H. A. Articles by Rhodes, C. H. Search for Related Content PubMed PubMed Citation Articles by Wishart, H. A. Articles by Rhodes, C. H. Related Collections MRI Volumetric MRI All Neuropsychology/Behavior All Cognitive Disorders/Dementia Cognitive aging

Regional brain atrophy in cognitively intact adults with a single APOE 4 allele

From the Departments of Psychiatry (H.A.W., A.J.S., T.W.M., L.A.R., B.C.M., L.A.F., R.M.R.), Radiology (A.J.S., A.C.M.), and Pathology (G.J.T., C.H.R.), Dartmouth Medical School, Lebanon, NH.

Address correspondence and reprint requests to Dr. H. Wishart, Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School/DHMC, One Medical Center Drive, Lebanon, NH 03756-0001.

Objective: To determine whether cognitively intact adults with the APOE 3/4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the 3 allele.

Methods: Participants were healthy, cognitively intact, right-handed adults, age 19 to 80, who completed genotyping, neuropsychological testing, and MRI. Forty-nine participants had the 3/3 genotype and 27 had the 3/4 genotype. Gray matter data were analyzed using the general linear model as implemented in the Statistical Parametric Mapping package, adjusting for age and sex.

Results: The 3/4 participants showed lower gray matter density than the 3/3 participants in right medial temporal and bilateral frontotemporal regions as well as other areas. There were no regions in which 3/4 participants showed higher gray matter density than 3/3 participants.

Conclusions: Regionally reduced gray matter density is detectable in cognitively intact adults with a single copy of the APOE 4 allele.

Supported by the National Institute on Aging (R01 AG19771), Alzheimer's Association (Hedco Foundation), Hitchcock Foundation, National Alliance for Medical Imaging Computing (NA-MIC, NIH U54 EB005149, NIGMS/NIH), National Science Foundation, and New Hampshire Hospital.

Disclosure: The authors report no conflicts of interest.

Received August 1, 2005. Accepted in final form May 24, 2006.

This article has been cited by other articles:

				E. M. Fine, D. C. Delis, S. R. Wetter, M. W. Jacobson, A. J. Jak, C. R. McDonald, J. C. Braga, L. J. Thal, D. P. Salmon, and M. W. Bondi Cognitive Discrepancies Versus APOE Genotype as Predictors of Cognitive Decline in Normal-Functioning Elderly Individuals: A Longitudinal Study Am J Geriatr Psychiatry, May 1, 2008; 16(5): 366 - 374. [Abstract] [Full Text] [PDF]

				L. Calderon-Garciduenas, A. C. Solt, C. Henriquez-Roldan, R. Torres-Jardon, B. Nuse, L. Herritt, R. Villarreal-Calderon, N. Osnaya, I. Stone, R. Garcia, et al. Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid {beta}-42 and {alpha}-Synuclein in Children and Young Adults Toxicol Pathol, February 1, 2008; 36(2): 289 - 310. [Abstract] [Full Text] [PDF]