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Published online before print August 16, 2006, doi:10.1212/01.wnl.0000233831.87781.a9)
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NEUROLOGY 2006;67:1251-1253
© 2006 American Academy of Neurology
Brief Communications

Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients

J. M. Leung, MD, MPH, L. P. Sands, PhD, M. Rico, BS, K. L. Petersen, MD, M. C. Rowbotham, MD, J. B. Dahl, MD, C. Ames, MD, D. Chou, MD and P. Weinstein, MD

From the Departments of Anesthesia & Perioperative Care (J.M.L., M.R.), Neurology (K.L.P., M.C.R.), and Neurological Surgery (C.A., D.C., P.W.), University of California, San Francisco; Purdue University (L.P.S.), School of Nursing, West Lafayette, IN; and Glostrup University Hospital (J.B.D.), Glostrup, Denmark.

Address correspondence and reprint requests to Dr. Jacqueline M. Leung, University of California, San Francisco, Department of Anesthesia and Perioperative Care, 521 Parnassus, San Francisco, CA 94143-0648; e-mail: leungj{at}anesthesia.ucsf.edu

In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.

Editorial, see page 1116

This article was previously published in electronic format as an Expedited E-Pub on August 16, 2006, at www.neurology.org.

Supported in part by institutional funds and the National Institute of Aging, National Institutes of Health, Grant #1K24 AG00948-05 (J.M.L.).

Disclosure: Dr. Rowbotham consults for, and owns stock in, a company developing an analog of gabapentin, an investigational agent.

Received February 20, 2006. Accepted in final form June 7, 2006.




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