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Clinical features associated with impulse control disorders in Parkinson disease

From the Departments of Psychiatry and Behavioral Sciences (G.P., S.S.B., L.M.) and Mental Health (J.R.W.), Bloomberg School of Public Health, Department of Neurology (L.M.), and Morris K. Udall Parkinson's Disease Research Center of Excellence at Johns Hopkins (J.R.W., S.S.B., L.M.), Johns Hopkins University School of Medicine, Baltimore, MD.

Address correspondence and reprint requests to Dr. Laura Marsh, Johns Hopkins University School of Medicine, 600 N. Wolfe Street–Phipps 300, Baltimore, MD 21287; e-mail: lmarsh{at}jhmi.edu

In patients with Parkinson disease (PD), impulse control disorders (ICDs) such as hypersexuality and pathologic gambling and shopping can be devastating complications of antiparkinsonian treatment. To improve their detection, we investigated clinical features associated with ICDs. Subjects were participants in a longitudinal study of PD. ICDs were associated with use of dopamine agonists and depressed mood, disinhibition, irritability, and appetite disturbance.

Editorial, see page 1118

See also page 1254

Supported in part by grants from the NIH: NIH R01-HD39822 (S.S.B.), T32-MH14592, the Morris K. Udall PD Research Center of Excellence at Johns Hopkins (NIH P50-NS-58377), and the General Clinical Research Center at Johns Hopkins University School of Medicine (National Center for Research Resources/NIH M01-RR00052).

Disclosure: The authors report no conflict of interest.

Presented at the World Parkinson's Congress; Washington, DC, February 22–26, 2006.

Received February 27, 2006. Accepted in final form June 6, 2006.

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