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NEUROLOGY 2006;67:1265-1267
© 2006 American Academy of Neurology
Brief Communications

Speech and language delay are early manifestations of juvenile-onset Huntington disease

G. Yoon, MD, FRCP(C), J. Kramer, PsyD, A. Zanko, MS, M. Guzijan, MS, S. Lin, MSW, A. Foster-Barber, MD, PhD and A. L. Boxer, MD, PhD

From the Division of Medical Genetics, Department of Pediatrics (G.Y., A.Z.), Memory and Aging Center (G.Y., J.K., A.Z., M.G., S.L., A.L.B.), Department of Neurology, Division of Child Neurology (A.F.-B.), University of California, San Francisco. Dr. Yoon is currently with The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Address correspondence and reprint requests to Dr. Adam L. Boxer, Memory and Aging Center, Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, Suite 706, Box 1207, San Francisco, CA, 94143-1207; e-mail: aboxer{at}memory.ucsf.edu

The neurocognitive features of juvenile-onset Huntington disease (HD) are not well understood. We present three patients with onset of HD symptoms before age 10 years in whom speech delay was the first symptom. Speech delay predated motor symptoms by at least 2 years, and language function was consistently impaired on formal testing. Screening for speech delay is particularly important in children with a family history of HD.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the October 10 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received February 20, 2006. Accepted in final form June 6, 2006.




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[Abstract] [PDF]

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 NeurologyHome page
P. B. Rosenberger, A. L. Boxer, and G. Yoon
Speech and language delay are early manifestations of juvenile-onset Huntington disease
Neurology, April 17, 2007; 68(16): 1325 - 1325.
[Full Text] [PDF]

Correspondence:

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Speech and language delay are early manifestations of juvenile-onset Huntington disease
Peter B. Rosenberger, MD
Neurology Online, 12 Dec 2006 [Full text]
Reply from the Authors
Adam L. Boxer, et al.
Neurology Online, 12 Dec 2006 [Full text]

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