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 Volume 67, Number 7, October 10, 2006
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NEUROLOGY 2006;67:1272-1274
© 2006 American Academy of Neurology
Brief Communications

Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP

Sung B. Lee, MD, Edward M. Manno, MD, Kennith F. Layton, MD and Eelco F.M. Wijdicks, MD

From the Division of Critical Care Neurology (S.B.L., E.M.M., E.F.M.W.) and Division of Neuroradiology (K.F.L.), Mayo Clinic College of Medicine, Rochester, Minnesota.

Address correspondence and reprint requests to Dr. Eelco F.M. Wijdicks, Mayo Clinic College of Medicine, Division of Critical Care Neurology, Department of Neurology, W8B, 200 First Street SW, Rochester, MN 55905; e-mail: wijde{at}mayo.edu

To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the October 10 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received September 16, 2005. Accepted in final form June 15, 2006.




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A. A. Rabinstein and E. F. M. Wijdicks
Determinants of Outcome in Anticoagulation-Associated Cerebral Hematoma Requiring Emergency Evacuation
Arch Neurol, February 1, 2007; 64(2): 203 - 206.
[Abstract] [Full Text] [PDF]


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