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Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

From the Department of Neurology and Neurosurgery, Washington University School of Medicine, St. Louis, MO.

Address correspondence and reprint requests to Dr. John R. Rinker II, Campus Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110; e-mail: rinkerj{at}neuro.wustl.edu

Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels 1.53 µg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).

Supported by the Barnes-Jewish Hospital Foundation. Dr. Rinker was supported by the Washington University Department of Neurology NIH-Sponsored Post-Doctoral Training Grant (T32 NS007205). Dr. Cross was supported in part by the Manny and Rosalyn Rosenthal-Dr. John L. Trotter MS Center Chair in Neuroimmunology.

Disclosure: The authors report no conflicts of interest.

Received October 19, 2005. Accepted in final form June 16, 2006.

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