Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rinker, J. R.
Right arrow Articles by Cross, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rinker, J. R., II
Right arrow Articles by Cross, A. H.
Related Collections
Right arrow All Immunology
Right arrow Prognosis
Right arrow Cerebrospinal Fluid
Right arrow Multiple sclerosis
NEUROLOGY 2006;67:1288-1290
© 2006 American Academy of Neurology
Brief Communications

Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

John R. Rinker, II, MD, Kathryn Trinkaus, PhD and Anne H. Cross, MD

From the Department of Neurology and Neurosurgery, Washington University School of Medicine, St. Louis, MO.

Address correspondence and reprint requests to Dr. John R. Rinker II, Campus Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110; e-mail: rinkerj{at}neuro.wustl.edu

Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels ≥ 1.53 µg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).

Supported by the Barnes-Jewish Hospital Foundation. Dr. Rinker was supported by the Washington University Department of Neurology NIH-Sponsored Post-Doctoral Training Grant (T32 NS007205). Dr. Cross was supported in part by the Manny and Rosalyn Rosenthal-Dr. John L. Trotter MS Center Chair in Neuroimmunology.

Disclosure: The authors report no conflicts of interest.

Received October 19, 2005. Accepted in final form June 16, 2006.




This article has been cited by other articles:


Home page
 Mult SclerHome page
M Thangarajh, J Gomez-Rial, A. Hedstrom, J Hillert, J. Alvarez-Cermeno, T Masterman, and L. Villar
Lipid-specific immunoglobulin M in CSF predicts adverse long-term outcome in multiple sclerosis
Multiple Sclerosis, November 1, 2008; 14(9): 1208 - 1213.
[Abstract] [PDF]

Home page
 NeurologyHome page
J. R. Rinker II, K. Trinkaus, R. T. Naismith, and A. H. Cross
Higher IgG index found in African Americans versus Caucasians with multiple sclerosis
Neurology, July 3, 2007; 69(1): 68 - 72.
[Abstract] [Full Text] [PDF]