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© 2006 American Academy of Neurology Brief Communications Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosisFrom the Department of Neurology and Neurosurgery, Washington University School of Medicine, St. Louis, MO. Address correspondence and reprint requests to Dr. John R. Rinker II, Campus Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110; e-mail: rinkerj{at}neuro.wustl.edu
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels
Supported by the Barnes-Jewish Hospital Foundation. Dr. Rinker was supported by the Washington University Department of Neurology NIH-Sponsored Post-Doctoral Training Grant (T32 NS007205). Dr. Cross was supported in part by the Manny and Rosalyn Rosenthal-Dr. John L. Trotter MS Center Chair in Neuroimmunology. Disclosure: The authors report no conflicts of interest. Received October 19, 2005. Accepted in final form June 16, 2006.
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