Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow CME: Take the course for this article:
 Volume 67, Number 8, October 24, 2006
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leonard, J. R.
Right arrow Articles by Gutmann, D. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leonard, J. R.
Right arrow Articles by Gutmann, D. H.
Related Collections
Right arrow All Oncology
Right arrow Primary brain tumor
Right arrow Neurofibromatosis
NEUROLOGY 2006;67:1509-1512
© 2006 American Academy of Neurology
Brief Communications

The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1

J. R. Leonard, MD, A. Perry, MD, J. B. Rubin, MD, PhD, A. A. King, MD, M. R. Chicoine, MD and D. H. Gutmann, MD, PhD

From the Departments of Neurosurgery (J.R.L., M.R.C.), Pathology and Immunology (A.P.), Pediatrics (J.B.R., A.A.K.), Division of Hematology/Oncology, and Neurology (D.H.G.), St. Louis Children's Hospital and Washington University School of Medicine, St. Louis, MO.

Address correspondence and reprint requests to Dr. David H. Gutmann, Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110; e-mail: gutmannd{at}wustl.edu.

Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 patients with NF1-associated gliomas. Biopsy showed that 9 were not classic PAs. These data highlight the value of biopsy in NF1-associated gliomas with unusual clinical or radiographic presentations.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the October 24 issue to find the title link for this article.

Supported by Schnuck Markets, Inc. (D.H.G.).

Disclosure: The authors report no conflicts of interest.

Received February 9, 2006. Accepted in final form June 23, 2006.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
B. Hegedus, D. Banerjee, T.-H. Yeh, S. Rothermich, A. Perry, J. B. Rubin, J. R. Garbow, and D. H. Gutmann
Preclinical Cancer Therapy in a Mouse Model of Neurofibromatosis-1 Optic Glioma
Cancer Res., March 1, 2008; 68(5): 1520 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncolHome page
Y. Sawamura, K. Kamada, Y. Kamoshima, S. Yamaguchi, T. Tajima, J. Tsubaki, and T. Fujimaki
Role of surgery for optic pathway/hypothalamic astrocytomas in children
Neuro-oncol, January 1, 2008; 10(5): 725 - 733.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.