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NEUROLOGY 2006;67:1684-1686
© 2006 American Academy of Neurology
Brief Communications

Pathologic laughing and intractable hiccups can occur early in multiple sclerosis

J. de Seze, MD, H. Zephir, MD, P. Hautecoeur, MD, A. Mackowiak, MD, M. Cabaret, MD and P. Vermersch, MD

From the Departments of Neurology, CHU of Lille (J.d.S., H.Z., M.C., P.V.) and Saint-Philibert Hospital, Lomme (P.H., A.M.), France.

Address correspondence and reprint requests to P. Vermersch, Department of Neurology, Hôpital R. Salengro, CHRU de Lille, 59037 Lille Cedex, France; e-mail: pvermersch{at}chru-lille.fr

Pathologic laughing occurs in approximately 10% of patients with multiple sclerosis (MS), especially when patients have entered the chronic stage. We describe four patients with MS who, at an early stage, developed pathologic laughing associated, in two cases, with intractable hiccups. In two patients, MRI showed an enhanced lesion in the medulla oblongata and the mesencephalon, two regions suspected of being involved in pathologic laughing and intractable hiccups.

Disclosure: The authors report no conflicts of interest.

Received March 28, 2006. Accepted in final form July 7, 2006.




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J Am Osteopath Assoc, August 1, 2008; 108(8): 409 - 411.
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