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 Volume 67, Number 9, November 14, 2006
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NEUROLOGY 2006;67:1692-1694
© 2006 American Academy of Neurology
Brief Communications

Immune reconstitution inflammatory syndrome associated with PML in AIDS: A treatable disorder

J. V. Martinez, MD, J. V. Mazziotti, MD, E. D. Efron, MD, P. Bonardo, MD, R. Jordan, MD, G. Sevlever, MD, M. Martinez, MD, S. C. Verbanaz, MD, Z. Salazar Salazar, MD, M. Fernandez Pardal, MD and R. Reisin, MD

From the Infectious Diseases (J.V.M., E.D.D., R.J., S.C.V.), Neurology (J.V.M., P.B., P.F., R.R.), and Radiology (M.M.) Departments, Hospital Británico, Pathology Department (G.S.), Instituto FLENI, and Neurology Department (Z.S.S.), HIGA San Martin, Buenos Aires, Argentina.

Address correspondence and reprint requests to Dr. R. Reisin, Neurology Department, Hospital Británico, Perdriel 74 (1280), Buenos Aires, Argentina; e-mail: rcreisin{at}intramed.net.ar

An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution inflammatory syndrome. Treatment with corticosteroids and transient suppression of HAART led to marked neurologic improvement.

Disclosure: The authors report no conflicts of interest.

Received December 16, 2005. Accepted in final form July 11, 2006.


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