Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print August 30, 2006, doi:10.1212/01.wnl.0000238963.07425.d5)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow All Versions of this Article:
01.wnl.0000238963.07425.d5v1
01.wnl.0000238963.07425.d5v2
67/9/1698    most recent
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tiangyou, W.
Right arrow Articles by Chinnery, P. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tiangyou, W.
Right arrow Articles by Chinnery, P. F.
Related Collections
Right arrow Parkinson's disease/Parkinsonism
Right arrow All Genetics
Right arrow Mitochondrial disorders
NEUROLOGY 2006;67:1698-1700
© 2006 American Academy of Neurology
Brief Communications

POLG1 in idiopathic Parkinson disease

W. Tiangyou, MSc, G. Hudson, PhD, D. Ghezzi, PhD, G. Ferrari, PhD, M. Zeviani, MD, PhD, D. J. Burn, FRCP and P. F. Chinnery, PhD, FRCP

From the Department of Neurology (W.T., G.H., D.J.B., P.F.C.) and Institute of Human Genetics (P.F.C.), The University of Newcastle upon Tyne, UK; Unit of Molecular Neurogenetics (D.G., G.F., M.Z.), Pierfranco and Luisa Mariani Center for the Study of Children’s Mitochondrial Disorders, National Neurological Institute, Milan, Italy; and Department of Neurology (D.J.B., P.F.C.), Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, UK.

Address correspondence and reprint requests to Dr. Patrick F. Chinnery, M41014, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH UK; e-mail: p.f.chinnery{at}ncl.ac.uk

We studied POLG1 in 140 UK patients with idiopathic Parkinson disease (PD) and 279 Italian patients with PD and compared them to a UK control group (n = 207) and an Italian control group (n = 285). Our observations do not support a role for common POLG1 genetic variants in PD and indicate that dominant POLG1 mutations are a rare cause of parkinsonism in the general population.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 14 issue to find the title link for this article.

This article was previously published in electronic format as an Expedited E-Pub on August 30, 2006, at www.neurology.org.

Funded by the Rhoda Lockhart Trust. P.F.C. is a Wellcome Trust Senior Fellow in Clinical Science and also receives funding from Ataxia (UK), the Alzheimer’s Research Trust, the Association Française contre les Myopathies, the United Mitochondrial Diseases Foundation, and the EU FP program EUmitocombat and MITOCIRCLE. M.Z. receives support from Fondazione Telethon-Italy (GGP030039) and Fondazione Pierfranco e Luisa Mariani, Italy.

Disclosure: The authors report no conflicts of interest.

Received April 5, 2006. Accepted in final form July 18, 2006.




This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
M. A. Graziewicz, R. J. Bienstock, and W. C. Copeland
The DNA polymerase {gamma} Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine
Hum. Mol. Genet., November 15, 2007; 16(22): 2729 - 2739.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.