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NEUROLOGY 2007;68:62-64
© 2007 American Academy of Neurology

Cognitive prognosis of patients with tuberous sclerosis complex

Elisabeth B. Winterkorn, MD, Margaret B. Pulsifer, PhD and Elizabeth A. Thiele, MD, PhD

From the Departments of Neurology (E.B.W., E.A.T.) and Psychiatry (M.B.P.), Massachusetts General Hospital, Boston.

Address correspondence and reprint requests to Dr Thiele, Herscot Center for Tuberous Sclerosis Complex, 175 Cambridge St., Suite 340, Boston, MA 02114; e-mail: ethiele{at}partners.org

To assess cognitive outcome in patients with tuberous sclerosis complex (TSC) and identify predictive risk factors, we reviewed records of 107 patients who underwent comprehensive neuropsychiatric evaluation. Fifty-seven percent of patients with TSC had normal-range IQ/developmental quotient (DQ). Cognitive outcome was strongly associated with refractory seizures and TSC2 mutation. In TSC, IQ/DQ is bimodally distributed, and more than half of individuals are in the normal range.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 2 issue to find the title link for this article.

Supported by the Carol and James Herscot Center for Tuberous Sclerosis Complex.

Disclosure: The authors report no conflicts of interest.

Received May 8, 2006. Accepted in final form September 20, 2006.




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