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NEUROLOGY 2007;68:1223-1226
© 2007 American Academy of Neurology

Physical activity and white matter lesion progression

Assessment using MRI

L. J. Podewils, MS, PhD, E. Guallar, MD, DrPH, N. Beauchamp, MD, C. G. Lyketsos, MD, L. H. Kuller, MD, DrPH and P. Scheltens, MD

From the Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (L.J.P., E.G.); Centers for Disease Control and Prevention, Atlanta, GA (L.J.P.); Welch Center for Prevention, Epidemiology, and Clinical Research (E.G.) and Department of Geriatric Psychiatry and Neuropsychiatry (C.G.L.), The Johns Hopkins Medical Institutions, Baltimore, MD; Department of Radiology, University of Washington School of Medicine, Seattle, WA (N.B.); Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA (L.H.K.); and Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands (P.S.).

Address correspondence and reprint requests to Dr. Laura Jean Podewils, 1600 Clifton Road, NE MS-E10, Atlanta, GA 30333; e-mail: lpp8{at}cdc.gov

We evaluated the association between physical activity and changes in white matter lesions (WMLs) on MRI in a sample of 179 older adults comprising 59 incident cases of Alzheimer disease, 60 persons with mild cognitive impairment, and 60 persons who remained cognitively stable over a median 5-year follow-up. Physical activity was not significantly associated with a decreased rate of periventricular or deep WML progression.

Supported by contracts N01-HC-85079 through N01-HC 85086, N01-HC-35129, and N01-HC-15103 from the National Heart, Lung, and Blood Institute (NHLBI), and grant AG15928 from the National Institute on Aging. The Cardiovascular Health Study (CHS) is conducted and supported by the NHLBI in collaboration with the Cardiovascular Health Study Investigators. This manuscript has been reviewed by CHS and by NHLBI for scientific content and consistency of data interpretation with previous Cardiovascular Health Study publications; substantive comments have been incorporated before submission for publication.

Disclosure: The authors report no conflicts of interest.

Received January 14, 2004. Accepted in final form December 1, 2006.






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