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NEUROLOGY 2007;68:1495-1500
© 2007 American Academy of Neurology

A population-based survey of multiple sclerosis in Shanghai, China

Q. Cheng, MD, PhD, L. Miao, MD, J. Zhang, MD, S. -J. Ding, MD, Z. -G. Liu, MD, X. Wang, MD, X. -J. Sun, MD, Z. -X. Zhao, MD, Y. -J. Song, MD, X. -Y. Ding, MD, Z. -L. Guo, MD, Y. Yang, MD, S. -D. Chen, MD, PhD, G. -X. Jiang, MD, PhD and S. Fredrikson, MD, PhD

From the Departments of Neurology (Q.C., J.Z., Y.-J.S, Z.-L.G, Y.Y, S.-D.C.) and Radiology (X.-Y.D), Ruijin Hospital; School of Public Health (Q.C., G.-X.J.); Department of Neurology (L.M.), Renji Hospital; Department of Neurology (Z.-G.L.), Xinhua Hospital; Department of Neurology (X.-J.S.), Shanghai No. 6 People's Hospital affiliated with Medical School of Shanghai Jiao Tong University, Shanghai; Endocrine and Metabolic Division (Q.C.), E-institutes of Shanghai Universities, Shanghai; Department of Neurology (S.-J.D.), Changhai Hospital; Department of Neurology (Z.-X.Z.), Changzheng Hospital affiliated with Second Military Medical University, Shanghai; Department of Neurology (X.W.), Zhongshan Hospital affiliated with Fudan University, Shanghai, China; Department of Public Heath Sciences (G.-X.J.), Division of Neurology (S.F.), Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden; and Institute of Health Science (S.-D.C.), Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Science (CAS) & Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Address correspondence and reprint requests to Dr. Guo-Xin Jiang, P.O. Box 230, Karolinska Institute, 17177 Stockholm, Sweden; and Drs. Sheng-Di Chen and Qi Cheng, 197 Ruijin Er Road, Department of Neurology, Ruijin Hospital, Shanghai 20025, P. R. Chinaguoijia{at}ki.se chen_sd{at}medmail.com.cn qicheng{at}shsmu.edu.cn

Objective: To conduct a large population-based survey on multiple sclerosis (MS) prevalence in Shanghai, China.

Methods: We established a network of physicians, mainly neurologists, for identifying prevalent patients with MS and systematically checked inpatient registers at each hospital in the study area for patients with a diagnosis of MS, neuromyelitis optica, or other demyelinating disorders. MS diagnosis in patients was validated by senior neurologists according to the McDonald criteria.

Results: In total, 123 patients with a validated MS diagnosis from the study population, 8.86 million inhabitants with permanent residence in Shanghai, were alive on the prevalence day. The crude MS prevalence rate was 1.39 cases per 100,000 inhabitants (95% CI: 1.16 to 1.66 cases) in the study population in Shanghai. There were 79 female and 44 male patients with MS, a female-to-male ratio of 1.8. Nearly all (96%) of the patients with validated MS had been examined by MRI.

Conclusion: Multiple sclerosis prevalence in Shanghai is in line with that reported for other Asian populations.

Supported by funds from Shanghai Science and Technology Commission (054107064), Natural Science Foundation of Shanghai, Second Medical University (04xj21003), and Endocrine and Metabolic Division, E-institutes of Shanghai Universities, Shanghai, China.

Disclosure: The authors report no conflicts of interest.

Received July 12, 2006. Accepted in final form January 3, 2007.




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