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Right arrow Dementia with Lewy bodies
NEUROLOGY 2007;68:1726-1729
© 2007 American Academy of Neurology

Cholinesterase inhibitors reduce cortical Aß in dementia with Lewy bodies

C. G. Ballard, MRCPsych, K. A. Chalmers, PhD, C. Todd, BA(Hons), I. G. McKeith, FRCPsych, J. T. O’Brien, FRCPsych, G. Wilcock, BSc, DM(Oxon), S. Love, FRCPath and E. K. Perry, DSc

From the Wolfson Centre for Age Related Diseases (C.G.B.), Kings College London, Institute of Clinical Neurosciences (K.A.C., G.W., S.L.), Frenchay Hospital, Bristol, and Wolfson Research Centre (C.T., I.G.M.K., J.T.O’B.) and IAH Research Labs (E.K.P.), Newcastle General Hospital, UK.

Address correspondence and reprint requests to Dr Perry, IAH Research Labs, Newcastle General Hospital, UK e.k.perry{at}ncl.ac.uk

Cholinesterase inhibitors (ChEIs) are effective symptomatic treatments in dementia with Lewy bodies (DLB), although effects on pathologic mechanisms are unknown. In the first human autopsy study examining the impact of ChEI treatment on brain pathology, we compared treated patients with DLB with matched untreated patients for cortical ß-amyloid (Aß) and tau pathologies. Treated patients with DLB had significantly less parenchymal Aß deposition, which is relevant to disease management and treatment of dementia patients using ChEI.

The Medical Research Council supported the study infrastructure.

Disclosure: The authors report no conflicts of interest.

Received June 13, 2006. Accepted in final form January 4, 2007.




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