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NEUROLOGY 2007;68:1944-1946
© 2007 American Academy of Neurology

A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS

D.J.L. MacGowan, MD, S. N. Scelsa, MD, T. E. Imperato, RN, K.-N Liu, MD, P. Baron, MS and B. Polsky, MD

From the ALS Center (D.J.L.M.), Department of Neurology (S.N.S., T.E.I.), Beth Israel Medical Center, Albert Einstein College of Medicine, New York; and Retrovirology Laboratory (K.-N.L., P.B., B.P.), St. Luke's Roosevelt Medical Center, New York, NY.

Address correspondence and reprint requests to Dr. Daniel J.L. MacGowan, 10 Union Square East, Suite 2Q, New York, NY 10003

Reverse transcriptase has been detected in the serum of HIV-negative patients with amyotrophic lateral sclerosis (ALS). An ALS-like disorder in HIV-positive patients can remit with antiretroviral therapy. Using the product enhanced assay technique, we measured reverse transcriptase activity in the serum and CSF of 23 HIV-negative patients with ALS and 21 neurologic disease controls. Results for CSF were not significant, whereas reverse transcriptase was detected in 56% of ALS sera vs 19% of controls.

dmacgow{at}bethisraelny.org

Supplemental data at www.neurology.org

Disclosure: The authors report no conflicts of interest.

Received February 17, 2006. Accepted in final form January 31, 2007.






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