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NEUROLOGY 2007;68:2031-2034
© 2007 American Academy of Neurology

A door-to-door survey of intracranial atherosclerosis in Liangbei County, China

K. S. Wong, MD, Y. N. Huang, MD, H. B. Yang, MD, S. Gao, MD, H. Li, MD, J. Y. Liu, MD, Y. Liu, MD and A. Tang, MPhil

From the Departments of Medicine & Therapeutics (K.S.W., H.L., A.T.), the Chinese University of Hong Kong, Shatin, Hong Kong SAR; Department of Neurology (Y.N.H., S.G., J.Y.L., Y.L.), Peking Union Medical College Hospital, Beijing; and Department of Neurology (Y.N.H.), Peking University First Hospital and Department of Neurology (H.B.Y.), Yuzhou City Hospital, Henan, China.

Address correspondence and reprint requests to Dr. Ka Sing Wong, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong ks-wong{at}cuhk.edu.hk

We studied 590 asymptomatic villagers aged ≥40 years in Liangbei County in central rural China and found 41 subjects (prevalence 6.9%) with intracranial atherosclerosis. In a multivariate analysis, the significant risk factors for intracranial stenosis were hypertension (OR 2.53; 95% CI 1.12 to 5.72), glycosuria (OR 3; 1.19 to 7.97), heart disease (OR 4; 1.39 to 11.6), and family history of stroke (OR 5.2; 1.38 to 20). Intracranial atherosclerosis is not uncommon among asymptomatic Chinese subjects.

See also page 2035

Supported by grant CUHK4280/97 from the Research Grant Council of the Research Grants Council of the University Grants Committee of Hong Kong. This project was awarded the Bruce S. Schoenberg International Award and Lecture in Neuroepidemiology by the American Academy of Neurology.

Disclosure: The authors report no conflicts of interest.

Received October 25, 2005. Accepted in final form January 21, 2007.


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