| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the New Jersey Institute for Successful Aging (D.J.L.), University of Medicine and Dentistry of New Jersey–School of Osteopathic Medicine; Department of Biostatistics and Epidemiology (S.X.X.), University of Pennsylvania; and Department of Neurology (P.M., J.F., S.A., G.M., K.C., M.G.), University of Pennsylvania School of Medicine, Philadelphia.
Address correspondence and reprint requests to Dr. David J. Libon, New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey–School of Osteopathic Medicine, Suite 1800, 42 East Laurel Rd., Stratford, NJ 08084; e-mail: libondj{at}UMDNJ.edu
Objective: To differentiate frontotemporal dementia (FTD) subtypes from each other and from probable Alzheimer disease (AD) using neuropsychological tests.
Methods: Patients with FTD and AD (n = 109) were studied with a comprehensive neuropsychological protocol at first contact. Data were subjected to a principal components analysis (PCA) to extract core neuropsychological features. A five-factor solution accounted for 72.89% of the variance and yielded factors related to declarative memory, working memory/visuoconstruction, processing speed/mental flexibility, lexical retrieval, and semantic memory.
Results: Between- and within-group analyses revealed that patients with AD obtain their lowest scores on tests of declarative memory while semantic dementia (SemD) patients are particularly disadvantaged on tests of semantic memory. On tests of processing speed/mental flexibility time to completion was faster for social comportment/dysexecutive (SOC/EXEC) patients, but these patients made more errors on some tests. Patients with corticobasal degeneration (CBD) and progressive nonfluent aphasia (PNFA) were impaired on tests of working memory. Logistic regression analyses using factor scores successfully assigned FTD subgroups and AD patients into their respective diagnostic categories.
Conclusion: Patients with differing frontotemporal dementia phenotypes can be distinguished from each other and from Alzheimer disease using neuropsychological tests.
Supported in part by the US Public Health Service (AG17586, AG15116, AG10124, and NS44266) and the Dana Foundation.
Disclosure: The authors report no conflicts of interest.
Received January 23, 2006. Accepted in final form October 6, 2006.
This article has been cited by other articles:
|
|
 |
|
  J. E. Peelle, V. Troiani, A. Wingfield, and M. Grossman Neural Processing during Older Adults' Comprehension of Spoken Sentences: Age Differences in Resource Allocation and Connectivity Cereb Cortex, August 7, 2009; (2009) bhp142v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. McCluskey, L. B. Elman, M. Martinez-Lage, V. Van Deerlin, W. Yuan, D. Clay, A. Siderowf, and J. Q. Trojanowski Amyotrophic Lateral Sclerosis-Plus Syndrome With TAR DNA-Binding Protein-43 Pathology Arch Neurol, January 1, 2009; 66(1): 121 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Koenig, E. E. Smith, V. Troiani, C. Anderson, P. Moore, and M. Grossman Medial Temporal Lobe Involvement in an Implicit Memory Task: Evidence of Collaborating Implicit and Explicit Memory Systems from fMRI and Alzheimer's Disease Cereb Cortex, December 1, 2008; 18(12): 2831 - 2843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Knopman, J. H. Kramer, B. F. Boeve, R. J. Caselli, N. R. Graff-Radford, M. F. Mendez, B. L. Miller, and N. Mercaldo Development of methodology for conducting clinical trials in frontotemporal lobar degeneration Brain, November 1, 2008; 131(11): 2957 - 2968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Bigal, D. Serrano, M. Reed, and R. B. Lipton Chronic migraine in the population: Burden, diagnosis, and satisfaction with treatment Neurology, August 19, 2008; 71(8): 559 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grossman, S. X. Xie, D. J. Libon, X. Wang, L. Massimo, P. Moore, L. Vesely, R. Berkowitz, A. Chatterjee, H. B. Coslett, et al. Longitudinal decline in autopsy-defined frontotemporal lobar degeneration Neurology, May 27, 2008; 70(22): 2036 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Bigal, S. Ashina, R. Burstein, M. L. Reed, D. Buse, D. Serrano, R. B. Lipton, and On behalf of the AMPP Group Prevalence and characteristics of allodynia in headache sufferers: A population study Neurology, April 22, 2008; 70(17): 1525 - 1533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Rohrer, W. D. Knight, J. E. Warren, N. C. Fox, M. N. Rossor, and J. D. Warren Word-finding difficulty: a clinical analysis of the progressive aphasias Brain, January 1, 2008; 131(1): 8 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Levy and G. J. Chelune Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease J Geriatr Psychiatry Neurol, December 1, 2007; 20(4): 227 - 238. [Abstract] [PDF]
|
|
|
|
|
|
M. Grossman, D. J. Libon, M. S. Forman, L. Massimo, E. Wood, P. Moore, C. Anderson, J. Farmer, A. Chatterjee, C. M. Clark, et al. Distinct Antemortem Profiles in Patients With Pathologically Defined Frontotemporal Dementia Arch Neurol, November 1, 2007; 64(11): 1601 - 1609. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
