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ApoE-4 is associated with reduced memory in long-standing intractable temporal lobe epilepsy

From the Departments of Psychiatry & Psychology (R.M.B., R.I.N.), Neurology (R.M.B., R.I.N., C.Q.T., I.M.N.), Anatomic Pathology (R.A.P.), and Neurosurgery (W.B.), Cleveland Clinic, Cleveland, OH; Department of Psychology, Butler University, Indianapolis, IN (T.T.L.); School of Education, University of Pittsburgh, Pittsburgh, PA (K.H.K.); and Department of Neurology, University of Texas Southwestern Medical School, Dallas, TX (Y.G., R.D.-A.).

Address correspondence and reprint requests to Dr. Robyn M. Busch, Department of Psychiatry & Psychology, Cleveland Clinic, 9500 Euclid Avenue, P57, Cleveland, OH 44195; e-mail: buschr{at}ccf.org

Objective: To investigate the relationship between the apolipoprotein (ApoE) 4 allele and memory performance (verbal and nonverbal) in patients with medically intractable temporal lobe epilepsy (TLE) who underwent temporal lobectomy.

Methods: Presurgical and postsurgical memory performance was examined in 87 adult patients with TLE (4 = 22; non-4 = 65) to determine whether the expression of ApoE-4 may be associated with memory performance in this population and to examine how this relationship may be affected by duration of epilepsy.

Results: There was a significant interaction between ApoE-4 status and duration of epilepsy such that 4 carriers with a long duration of epilepsy demonstrated the poorest memory performance on both verbal and nonverbal measures. This relationship was observed both before and after temporal lobectomy, with little change in test performance over time.

Conclusions: The ApoE-4 allele interacts with longstanding seizures to affect memory performance, both verbal and nonverbal, in patients with medically intractable temporal lobe epilepsy.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the February 6 issue to find the title link for this article.

Supported by the Epilepsy Foundation through the Postdoctoral Fellowship Program: Research and Training Fellowships for Clinicians. Additional support for this research was provided by the NIH (RO1 HD4817 and UO1 HD42652) and the US Department of Education (H133A02052601).

Disclosure: The authors report no conflicts of interest.

Received June 14, 2006. Accepted in final form October 13, 2006.

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February 6 Highlights

Neurology 2007 68: 397. [Full Text]  

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