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NEUROLOGY 2007;68:528-531
© 2007 American Academy of Neurology

Right-to-left shunt and lacunar stroke in patients without hypertension and diabetes

Y. Ueno, MD, K. Kimura, MD, Y. Iguchi, MD, K. Shibazaki, MD, T. Inoue, MD and T. Urabe, MD

From the Stroke Center, Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan (Y.U., K.K., Y.I., K.S., T.I.), and Department of Neurology, Juntendo University School of Medicine, Tokyo Japan (Y.U., T.U.).

Address correspondence and reprint requests to Dr. Yuji Ueno, Stroke Center, Department of Stroke Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki-city, Okayama, 701-0192, Japan; e-mail: yuji-u{at}med.juntendo.ac.jp

We analyzed the frequency of cardiac embolic sources in 62 patients with acute lacunar stroke vs 50 controls. In post hoc analysis, 11 patients with lacunar stroke having neither hypertension nor diabetes mellitus (non-HDM group) had a higher frequency of right-to-left shunt (RLS) (82%) than patients with risk factors for lacunar stroke. RLS was also independently associated with the non-HDM group. Thus, RLS may contribute to lacunar stroke in patients without risk factors for lacunar stroke.

Disclosure: The authors report no conflicts of interest.

Received March 1, 2006. Accepted in final form October 19, 2006.


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