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NEUROLOGY 2007;68:546-549
© 2007 American Academy of Neurology

APOE {varepsilon}4 is associated with impaired verbal learning in patients with MS

G. Koutsis, MB, BChir, M. Panas, MD, E. Giogkaraki, MSc, C. Potagas, MD, G. Karadima, PhD, C. Sfagos, MD and D. Vassilopoulos, MD, PhD

From the Department of Neurology, University of Athens, Aeginition Hospital, Greece.

Address correspondence and reprint requests to Dr. G. Koutsis, Department of Neurology, University of Athens, Aeginition Hospital, 74 Vas. Sophias Ave., Athens 11528, Greece; e-mail: gkoutsi2{at}otenet.gr

Objective: To investigate the effect of APOE {varepsilon}4 on different cognitive domains in a population of Greek patients with multiple sclerosis (MS).

Methods: A total of 125 patients with MS and 43 controls were included in this study and underwent neuropsychological assessment with Rao’s Brief Repeatable Battery. All patients with MS were genotyped for APOE. The effect of APOE {varepsilon}4 on different cognitive domains was investigated.

Results: Fifty-one percent of patients with MS were cognitively impaired. E4 carriers had a sixfold increase in the relative risk of impairment in verbal learning vs noncarriers (OR 6.28, 95% CI 1.74 to 22.69). This effect was domain-specific and was not observed in other cognitive domains assessed by the battery.

Conclusion: We found an association of APOE {varepsilon}4 with impaired verbal learning in patients with multiple sclerosis.

Disclosure: The authors report no conflicts of interest.

Received May 31, 2006. Accepted in final form November 7, 2006.


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Neurology, January 15, 2008; 70(3): 164 - 165.
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