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Comparison of CT perfusion and angiography and MRI in selecting stroke patients for acute treatment

From the Department of Radiology (M.W.), University of California, San Francisco; and Departments of Radiology (R.M., P.B., P.S.) and Neurology (M.R., P.M.), University Hospital (CHUV), Lausanne, and Department of Neurology (J.B.), Genolier Swiss Medical Network Valmont Clinic, Glion-sur-Montreux, Switzerland.

Address correspondence and reprint requests to Dr. M. Wintermark, Neuroradiology Section, Department of Radiology, University of California, San Francisco (UCSF), 505 Parnassus Ave., Box 0628, San Francisco, CA 94143-0628; e-mail: Max.Wintermark{at}radiology.ucsf.edu

Forty-two stroke patients successively underwent perfusion CT (PCT)/CT angiography (CTA) and MRI examinations within 3 to 9 hours following symptom onset; 14 would have been suitable candidates for reperfusion treatment based on MRI findings. Correlation between PCT/CTA and MRI was excellent for infarct size, cortical involvement, and internal cerebral artery occlusion and substantial for penumbra/infarct ratio. Relying on MRI or PCT/CTA would have led to the same treatment decisions in all cases but one.

Disclosure: Max Wintermark is a consultant for Paion GmbH and Forest Laboratories. The other authors report no conflicts of interest.

Received June 16, 2006. Accepted in final form November 7, 2006.

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