Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hesdorffer, D. C.
Right arrow Articles by Hauser, W. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hesdorffer, D. C.
Right arrow Articles by Hauser, W. A.
Related Collections
Right arrow Frontotemporal dementia
Right arrow Natural history studies (prognosis)
Right arrow Risk factors in epidemiology
NEUROLOGY 2007;69:73-78
© 2007 American Academy of Neurology

Recurrence of afebrile status epilepticus in a population-based study in Rochester, Minnesota

D. C. Hesdorffer, PhD, G. Logroscino, MD, PhD, G. D. Cascino, MD and W. A. Hauser, MD

From the Gertrude H. Sergievsky Center and Department of Neurology (D.C.H., W.A.H.), Division of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, Department of Epidemiology (G.L.), Harvard School of Public Health, Boston, MA, and Departments of Neurology and Health Sciences Research (G.D.C., W.A.H.), Mayo Clinic and Mayo Foundation, Rochester, MN.

Address correspondence and reprint requests to Dr Hesdorffer, G.H. Sergievsky Center, 630 W. 168 St., P&S Box 16, New York, NY 10032 dch5{at}columbia.edu

Objective: To determine the risk of recurrence of status epilepticus (SE) in a population-based sample and to identify risk factors for recurrence.

Methods: We ascertained all first episodes of afebrile SE in residents of Rochester, MN, through the Rochester Epidemiology Project’s records-linkage system between January 1, 1965, and December 31, 1984. Information was collected on age, gender, duration, seizure type, etiology, therapeutic response to initial antiepileptic drug medication, and subsequent episodes of SE.

Results: Among the 183 episodes of first afebrile SE, the risk of recurrent SE was 31.7% over a 10-year follow-up period. The risk of recurrence was about 25% for those with acute symptomatic SE, remote symptomatic SE, and idiopathic cryptogenic SE. Recurrence was 100% for those with progressive symptomatic SE. Female gender (rate ratio [RR] = 2.3, 95% CI = 1.1 to 5.0) and progressive symptomatic etiology (RR = 2.4, 95% CI = 0.6 to 8.9) increased the risk for recurrent SE. Both partial SE (RR = 0.5, 95% CI = 0.2 to 1.1) and good therapeutic response to the initial antiepileptic drug therapy (RR = 0.3, 95% CI = 0.1 to 0.7) were associated with a decreased risk of recurrent SE.

Conclusions: Status epilepticus (SE) recurs in about one-third of individuals with a first episode of SE. Except for SE occurring in the setting a progressive brain disorder, the risk of recurrence is about 25%, regardless of the underlying etiology. Female gender and lack of response to the first antiepileptic drug medication after the initial episode of SE identify those individuals at greatest risk for recurrence.

Supplemental data at www.neurology.org

Funded in part through grants from the National Institute of Neurological Disorders and Stroke (5-P50-NS-16308) to the University of Minnesota and NIH (MO1RR00645) to Columbia University.

Disclosure: The authors report no conflicts of interest.

Received November 22, 2006. Accepted in final form February 12, 2007.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by AAN Enterprises, Inc.