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NEUROLOGY 2007;69:196-199
© 2007 American Academy of Neurology

Brain volumes in Guam dementia vs Parkinson dementia complex vs aging Chamorro adults

J. A. Kaye, MD, M. M. Moore, BS, D. Galasko, MD, U. K. Craig, PhD, R. Adonay, BS and L. C. Silbert, MD

From the Departments of Neurology (J.A.K., M.M.M., L.C.S.), Oregon Health and Science University, Portland, OR, and University of California (D.G.), San Diego; and University of Guam (U.K.C., R.A.), Mangilao.

Address correspondence and reprint requests to Dr Kaye, Layton Aging and Alzheimer's Disease Center, CR-131, Oregon Health and Science University, 3181 Sam Jackson Park Rd., Portland, OR 97239 kaye{at}ohsu.edu

We sought to determine if Chamorro individuals with a family history of Guam dementia (GD) or Parkinson dementia complex (PDC) exhibit presymptomatic brain MRI changes. Sixty-six Chamorro subjects had neurocognitive assessment and volumetric MRI. MRI brain volumes differed between diagnostic groups (GD, PDC, control) and according to family history. Chamorros with a family history of PDC or dementia may have increased brain atrophy, suggesting a hereditary susceptibility to neurodegenerative disorders.

Supported by the National Institute of Aging NIH (PO1 AG014382 and P30 AG008017) and Department of Veterans Affairs.

Disclosure: The authors report no conflicts of interest.

Received April 5, 2006. Accepted in final form February 20, 2007.