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 Volume 69, Number 04, July 24, 2007
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NEUROLOGY 2007;69:356-359
© 2007 American Academy of Neurology

In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution

D. Weisman, MD, M. Cho, C. Taylor, PhD, A. Adame, L. J. Thal, MD and L. A. Hansen, MD

From the Departments of Neurosciences (D.W., C.T., L.J.T., L.A.H.) and Pathology (M.C., A.A., L.A.H.), University of California, San Diego, CA.

Address correspondence and reprint requests to Dr. David C. Weisman, 8950 Villa La Jolla Drive, Suite C227, La Jolla, CA 92037-1712 davew{at}graffiti.net

We used an autopsy series to determine whether the newest dementia with Lewy bodies (DLB) consensus pathologic classification correlates with premortem diagnosis of DLB. Neocortical sections from a total of 95 cases with Lewy bodies were stained with {alpha}-synuclein antibodies. We assigned cases according to the DLB consensus' categories and found a significant association with the premortem clinical diagnosis of DLB. Clinical diagnosis of DLB, however, depended on the presence of low Alzheimer disease pathology (by Braak staging) rather than on Lewy body distribution.

{dagger}Deceased.

Supported by grant AGO P50 5131 and a VA geriatric neurology fellowship.

Disclosure: The authors report no conflicts of interest.

Received March 14, 2006. Accepted in final form March 2, 2007.




This article has been cited by other articles:


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D. W. Dickson, H. Fujishiro, D.C. Weisman, M . Cho, C. Taylor, A. Adame, and L.A. Hansen
IN DEMENTIA WITH LEWY BODIES, BRAAK STAGE DETERMINES PHENOTYPE, NOT LEWY BODY DISTRIBUTION
Neurology, May 27, 2008; 70(22): 2087 - 2089.
[Full Text] [PDF]

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K. A. Jellinger
IN DEMENTIA WITH LEWY BODIES, BRAAK STAGE DETERMINES PHENOTYPE, NOT LEWY BODY DISTRIBUTION
Neurology, January 29, 2008; 70(5): 407 - 408.
[Full Text] [PDF]

Correspondence:

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In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
Kurt A. Jellinger
Neurology Online, 2 Oct 2007 [Full text]
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
Dennis W. Dickson, et al.
Neurology Online, 4 Dec 2007 [Full text]
Reply from the authors
David C. Weisman, MD, et al.
Neurology Online, 4 Dec 2007 [Full text]

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