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NEUROLOGY 2009;72:332-336
© 2009 American Academy of Neurology

TP53 codon 72 polymorphism is associated with age at onset of glioblastoma

S. El Hallani, MD, F. Ducray, MD, A. Idbaih, MD, PhD, Y. Marie, MSc, B. Boisselier, MSc, C. Colin, PhD, F. Laigle-Donadey, MD, M. Rodéro, MSc, O. Chinot, MD, J. Thillet, PhD, K. Hoang-Xuan, MD, PhD, J-Y Delattre, MD and M. Sanson, MD, PhD

From INSERM, U711 (S.E.H., F.D., A.I., Y.M., B.B., C.C., J.T., K.H.-X., J.-Y.D., M.S.), Biologie des Interactions Neurones & Glie, Paris; AP-HP (F.D., A.I., F.L.-D.), Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie Mazarin, Paris; Service de Neurologie B (F.D.), Hôpital Neurologique, Lyon; INSERM, U543 (M.R.), Laboratoire d’Immunologie Cellulaire, Paris; 5. Service de Neurochirurgie (O.C.), Hôpital de la Timone, Marseille; and Université Pierre et Marie Curie (K.H.-X., J.-Y.D., M.S.), Faculté de Médecine, Paris, France.

Address correspondence and reprint requests to Dr. Marc Sanson, Service de Neurologie Mazarin, Hôpital de la Salpêtrière, 47, Bd de l’Hôpital, 75013 Paris, France marc.sanson{at}psl.aphp.fr

Background: Functional single nucleotide polymorphisms (SNP) in codon 72 of TP53 have been shown to be a risk factor, a prognostic marker, and related factor to age at onset in various cancers.

Methods: We investigated blood samples from 254 patients with glioblastoma and 238 healthy controls.

Results: TP53 codon 72 status was not correlated with prognosis and did not differ between glioblastoma and control populations. However, the Pro/Pro genotype was overrepresented in patients <45 years (20.6% vs 6.4% in patients with glioblastoma >45 years, p = 0.002, vs 5.9% in control group, p = 0.001). We then confirmed this result on an independent series of young patients with glioblastoma. Finally, the analysis of tumor DNA found the Pro allele associated with occurrence of TP53 somatic mutation.

Conclusion: Our data suggest that TP53 functional variation is particularly critical for oncogenesis of glioblastoma in young patients.

Abbreviations: CI = confidence interval; GBM = glioblastoma multiforme; SNP = single nucleotide polymorphisms.

Supported by the Délégation à la Recherche Clinique (AP-HP; grant no. MUL 03012).

Disclosure: The authors report no disclosures.

Received July 17, 2008. Accepted in final form October 15, 2008.






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