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NEUROLOGY 2009;73:1054-1057
© 2009 American Academy of Neurology

Three-dimensional MR volumetric analysis of the posterior fossa CSF space in hemifacial spasm

L. -L. Chan, MD, K. -M. Ng, BSc, S. Fook-Chong, MSc, Y. -L. Lo, MD and E. -K. Tan, MD

From the Departments of Diagnostic Radiology (L.-L.C., K.-M.N.), Clinical Research (S.F.-C.), and Neurology (Y.-L.L., E.-K.), Singapore General Hospital; National Neuroscience Institute (Y.-L.L., E.-K.); and Duke-NUS Graduate Medical School (Y.-L.L., E.-K.), Republic of Singapore.

Address correspondence and reprint requests to Eng-King Tan, MD, FRCP(UK), Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore gnrtek{at}sgh.com.sg

Background: We hypothesize that a smaller posterior fossa (PF) CSF space may be a risk factor for hemifacial spasm (HFS).

Objective: We conducted a case-control 3-dimensional magnetic resonance (MR) volumetric study in patients with HFS and determined the clinical predictive factors of PF CSF volume.

Methods: Patients with clinically diagnosed HFS and controls matched for age, sex, race, and hypertension underwent MRI/magnetic resonance angiography examination. The PF CSF space was segmented and quantified on a heavily T2-weighted high-resolution 3-dimensional MR volume slab, centered over the porus acusticus.

Results: Eighty-two study subjects (41 patients and 41 controls) were included. The mean PF CSF volume in patients with HFS and controls was 17,303.0 ± 3,900.0 vs 19,216.0 ± 3,912.0 mm3. The mean volume in patients with HFS was 11.4% smaller than in controls (p = 0.015). Analysis of differences between individually matched pairs and controls also revealed that PF CSF for controls was larger than that for patients with HFS (p = 0.007). A multivariate linear regression analysis revealed that a small PF CSF volume was associated with HFS (p = 0.01). Decreasing age (p = 0.001) and female gender (p < 0.0005), but not hypertension (p = 0.892), were also found to be predictors of a low PF CSF volume.

Conclusions: Our results showed that the posterior fossa (PF) CSF volume was lower in patients with HFS compared with matched controls. HFS, female gender, and younger age were associated with smaller PF CSF volume. These observations could explain the strong female preponderance in both clinic- and population-based epidemiologic studies.

Abbreviations: CISS = constructive interference at steady state; FA = flip angle; HFS = hemifacial spasm; MR = magnetic resonance; MRA = magnetic resonance angiography; NEX = number of excitations; NVC = Neurovascular contact; PF = posterior fossa; TE = echo time; TR = repetition time.

Supported by a grant from the National Medical Research Council.

Disclosure: Author disclosures are provided at the end of the article.

Received March 9, 2009. Accepted in final form June 15, 2009.






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