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 Volume 66, Number 10, May 23, 2006
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NEUROLOGY 2006;66:1568-1570
© 2006 American Academy of Neurology
Brief Communications

Neuromyelitis optica diagnosis in clinically isolated syndromes suggestive of multiple sclerosis

M. Rubiera, MD, J. Río, MD, PhD, M. Tintoré, MD, PhD, C. Nos, MD, A. Rovira, MD, N. Téllez, MD and X. Montalban, MD, PhD

From Unitat de Neuroinmunologia Clínica (M.R., J.R., M.T., C.N., N.T., X.M.) and Unitat de Resonància Magnética-IDI (A.R.), Hospital Universitari Vall d’Hebrón, Barcelona, Spain.

Address correspondence and reprint requests to Dr. Xavier Montalban, Unitat de Neuroinmunologia Clínica, Hospital Universitari Vall d’Hebrón, Passeig Vall d’Hebrón 119-129, 08035 Barcelona, Spain; e-mail: xavier.montalban{at}unic-em.com

The authors assessed the extent of overlap between current diagnostic criteria of neuromyelitis optica (NMO) and multiple sclerosis (MS) by applying NMO criteria to a large cohort of 320 patients with clinically isolated syndromes (CIS). Twenty-three (7.2%) patients fulfilled NMO absolute criteria at some time and 1 (0.3%) also fulfilled one major supportive criterion. Therefore, even by systematically applying NMO criteria in patients with CIS, NMO diagnosis is reached infrequently.

Editorial, see page 1466

See also page 1485

Disclosure: The authors report no conflicts of interest.

Received October 6, 2005. Accepted in final form February 23, 2006.


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