Neurology
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Linda C. Wendell, MD, Stefanie H. Freeman, MD, Scott R. Plotkin, MD, PhD and John R. Sims, MD

From the Department of Neurology, Rhode Island Hospital/Brown University, Providence, RI (L.C.W.); and Department of Pathology (S.H.F.), Department of Neurology (S.R.P.), and Stroke and Neurocritical Care, Departments of Neurology and Radiology (J.R.S.), Massachusetts General Hospital/Harvard Medical School, Boston, MA.


Figure 112
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Figure 1 Noncontrast CT image of left frontal lobar hemorrhage at presentation

 

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Figure 2 Brain MRI: gadolinium (A) and susceptibility (B); cardiac imaging: MRI (C) and PET (D)

(A) MRI performed 4 days after initial head CT, T1 sequence with gadolinium, shows left lobar lesion and right frontal lesion at the gray–white junction with enhancement (arrow) and a suggestion of occipital leptomeningeal enhancement (arrow). (B) MRI susceptibility sequence shows right frontal lesion has decreased intensity (arrow) consistent with hemorrhage. (C) Cardiac MRI shows a nonmobile mass (arrow) attached to the left atrial wall. (D) Whole body PET scan demonstrates focal fluorodeoxyglucose uptake (arrow) superior to the left ventricle, which localizes to the intra-atrial mass seen on cardiac MRI.

 

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Figure 3 Immunohistochemical evaluation of the brain biopsy

Brain biopsy revealed a densely cellular tumor composed of pleomorphic cells with both epithelioid and spindle cell components, within a background of reactive brain with areas of inflammation and necrosis (hematoxylin and eosin, 20x).

 

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Figure 4 Brain MRI: FLAIR (A) and zero B (B)

(A) MRI, performed 7 months after initial presentation and 1 month after completing chemotherapy, shows two large bilateral occipital lobe lesions which caused acute blindness. (B) MRI, zero-b sequence shows both occipital lesions are low intensity, consistent with bilateral hemorrhages.

 





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