Figure 2. Individual neuropsychological and MRS data: longitudinal study. Mattis score (A, B) and frontal NAA/Cr (C, D) evolution in cognitively unimpaired (CU) (A, C) and impaired (B, D) patients. Normal mean (black arrow) and range (white arrowhead) of NAA/Cr. White circles correspond to the three patients with leukoencephalopathy. White triangles correspond to the single CU patient with cognitive decline. Note that he was also the only CU patient with a decrease of NAA/Cr ratio throughout follow-up.
