Figure 3. Concentration-dependent reduction in peak current amplitude by Miller Fisher syndrome (MFS) immunoglobulin G (IgG) from Patient 5. Amplitudes of single pulses of 1.0 mM acetylcholine to an outside-out patch were plotted versus time. Pulses were applied with a frequency of 0.25 Hz. The horizontal bars indicate duration of IgG application at the respective IgG concentration. Note that the reduction in peak current amplitude comes on faster and is more pronounced with high antibody concentrations.
