Data Supplement

One figure and three tables; one PDF file and three Word documents.

Files in this Data Supplement:

• E1 - Figure; PDF file.
• E2 - Table (E)T-1. MRI scanner acquisition parameters; Word document.
• E3 - Table (E)T-2. Effect of AN1792(QS-21) or placebo on exploratory measures in the MRI efficacy-evaluable population. Patients were included in the analysis if they had evaluable paired MRI scans. Patients were considered antibody responders if they had a serum anti-AN1792 IgG (total) titer >/=1:2200 at any time after injection 1. Data were analyzed using ANCOVA; Word document.
• E4 - Table (E)T-3. Effect of AN1792(QS-21) or placebo on neuropsychological test battery measures in the MRI efficacy-evaluable population. Patients were included in the analysis if they had evaluable paired MRI scans. Patients were considered antibody responders if they had a serum anti-AN1792 IgG (total) titer >/= 1:2200 at any time after injection 1. Data were analyzed using ANCOVA. Negative values for the difference in the mean change indicate a tendency for antibody responders to perform better than placebo patients; Word document.