Data Supplement

Six tables and one appendix; seven Word documents.

Files in this Data Supplement:

• E1 - Table (E)T-1: Mean (s.d.) UHDRS score at baseline and 12 months in patients with HD (N=13); Word document.
• E2 - Table (E)T-2a: Mean (sd) brain volumes (uncorrected and corrected for TIV) and mean TIV at baseline and 6 months, and change over 6 months from these measures and the BBSI; Table (E)T-2b: Rates of atrophy over 6 months calculated from the measurements in Table (E)T-2a, with differences adjusted for age; Word document.
• E3 - Table (E)T-3 Mean (s.d.) neuropsychological performance at baseline, with and without adjustment for age and estimated premorbid IQ; Word document.
• E4 - Table (E)T-4: Mean (s.d.) neuropsychological change from baseline to 6 months in patients and controls, with and without adjustment for baseline score; Word document.
• E5 - Table (E)T-5: Mean (s.d.) neuropsychological change from baseline to 12 months in patients and controls, with and without adjustment for baseline score; Word document.
• E6 - Table (E)T-6: Correlation coefficientsa in the HD group between cognitive, clinical and volumetric variables, and brain volume (standardised for TIV), CAG repeat length, and disease duration at baseline; Word document.
• E7 - Appendix; Word document.