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Figure Relative efficacy of doxycycline vs parenteral treatment
Relative efficacy of doxycycline vs parenteral treatment (ratio of response rate to doxycycline to response rate to parenteral penicillin or ceftriaxone; RR of 1.0 indicating identical response rates with the agents being compared) in eight studies, and in aggregate. Responses in most studies were judged clinically; in study 6, CSF criteria were used as well. For summed data, RR is 0.986 (95% CIs 0.948 to 1.025). Additional analyses of doxycycline vs parenteral penicillin or ceftriaxone individually and of parenteral penicillin vs ceftriaxone similarly showed no significant differences. Key to studies: #127; #219; #315; #434; #514; #620; #733; #835.
