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Retraction for Walz et al., Neurology 61 (9) 1204-1210.
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NEUROLOGY 2007;69:405
© 2007 American Academy of Neurology
Retraction

Voluntary Retraction of: Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant

Authors’ voluntary retraction: In the article "Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant" (Neurology® 2003;61:1204–1210) by R. Walz et al. , the authors reported that a variant allele at the cellular prion protein gene (PRNP) Asn171Ser was highly prevalent in patients with medically untreatable mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) and influences their surgical outcome. Unfortunately, a second researcher in the group was unable to reproduce these results when reevaluating 90% of the patient samples. The accurate data presented in the table demonstrate that the PRNP variant allele Asn171Ser was not correlated with MTLE-HS. However, the present results point to a moderate difference in the distribution of the variant allele Val129Val in MTLE-HS patients and healthy controls (p = 0.017; OR = 3.38; 95% CI = 1.24–9.21), which deserves further investigation.


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  		Table Frequency of PRNP alleles in MTLE-HS patients and controls

 

Thus the authors would like to retract the paper and deeply apologize for unintentionally permitting incorrect data to reach the scientific community.





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