Data Supplement

Five tables; five Word documents.

Files in this Data Supplement:

• E1 - Table (E)T-1: Additional clinical features and evolution over time; Word document.
• E2 - Table (E)T-2: Quotations from patients illustrating the nature of the pain in PEPD; Word document.
• E3 - Table (E)T-3: Response to medications tried in the 15 families; Word document.
• E4 - Table (E)T-4: Results from the neuropathic pain questionnaire completed by 14 affected individuals. Each feature could be scored from 0 (minimum) to 10 (maximum); Word document.
• E5 - Table (E)T-5: Summary of histopathological examination of various tissues from subjects with PEPD; Word document.