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Published online before print April 7, 2005, doi:10.1212/01.WNL.0000158328.26897.0D)
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Received June 2, 2004
Accepted December 13, 2004

Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine

M. Cherner PhD*, S. Letendre MD, R. K. Heaton PhD, J. Durelle BS, J. Marquie-Beck BA, B. Gragg BS, I. Grant MD, and the HIV Neurobehavioral Research Center Group

From the Departments of Psychiatry (Drs. Cherner, Heaton, and Grant) and Medicine (Dr. Letendre, J. Durelle, J. Marquie-Beck, and B. Gragg), University of California San Diego, and VA San Diego Healthcare System (Dr. Grant), CA.


* To whom correspondence should be addressed. E-mail: mcherner{at}ucsd.edu.

Abstract-- Objective: To examine the contribution of hepatitis C virus (HCV) infection to neurocognitive dysfunction in individuals with comorbid HIV infection or methamphetamine (METH) dependence. Methods: Neurocognitive functioning was examined in 430 study participants who were either normal controls or had HCV infection, HIV infection, history of METH dependence, or combinations of these factors as risks for cognitive deficits. Results: Rates of global and domain-specific neuropsychological (NP) impairment increased with the number of risk factors. HCV serostatus was a significant predictor of NP performance both globally and in the areas of learning, abstraction, and motor skills, with trends in speeded information processing and delayed recall. HCV serostatus did not predict scores in attention/working memory or verbal fluency. Conclusion: Hepatitis C virus infection contributes to the neuropsychological deficits observed among HIV-infected and stimulant-dependent populations.




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