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Published online before print May 25, 2005, doi:10.1212/01.WNL.0000166950.35189.5E)
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Received June 24, 2004
Accepted March 18, 2005

Infant botulism in the age of botulism immune globulin

J. A. Thompson MD*, F. M. Filloux MD, C. B. Van Orman MD, K. Swoboda MD, P. Peterson PNP, S. D. Firth PhD, MPH, and J. F. Bale Jr. MD

From the Division of Pediatric Neurology, Department of Pediatrics, The University of Utah and Primary Children's Medical Center, Salt Lake City.


* To whom correspondence should be addressed. E-mail: joel.thompson{at}hsc.utah.edu.

Abstract-- Infant botulism causes acute bulbar dysfunction, weakness, and respiratory failure in infants living in endemic regions of the United States. Until Food and Drug Administration approval of botulism immune globulin (BIG) in October 2003, management of infant botulism had changed little since the 1970s. Currently, IV therapy with BIG is advised to shorten the duration and diminish the potential complications of the disorder. This review describes two decades of experience with infant botulism and provides a contemporary perspective on the role and benefit of BIG.




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