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Published online before print June 15, 2005, doi:10.1212/01.WNL.0000168163.72351.f3)
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Received December 3, 2004
Accepted April 13, 2005

The smoking-thrombolysis paradox and acute ischemic stroke

Bruce Ovbiagele MD* and Jeffrey L. Saver MD

From the Stroke Center and Department of Neurology, UCLA Medical Center, and Department of Neurology, Olive View-UCLA Medical Center, Los Angeles, CA.


* To whom correspondence should be addressed. E-mail: Ovibes{at}mednet.ucla.edu.

Abstract-- Smokers with acute myocardial infarction have better outcomes after thrombolysis than nonsmokers. The authors evaluated the independent effect of smoking on short-term outcome following IV thrombolysis for acute ischemic stroke. After adjusting for covariates, recent smokers who received thrombolysis had a significantly greater drop in 24-hour median stroke severity scores from baseline than nonsmokers who received thrombolysis and lower mortality over 1 year.




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The smoking/thrombolysis paradox and acute ischemic stroke
Mark Fisher
Neurology Online, 31 Aug 2005 [Full text]
Reply to Fisher
Bruce Ovbiagele, et al.
Neurology Online, 31 Aug 2005 [Full text]

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