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Published online before print June 15, 2005, doi:10.1212/01.WNL.0000168259.94991.8a)
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Received January 25, 2005
Accepted March 29, 2005

A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster

James D. Berry BS and Karin Lottrup Petersen MD*

From UCSF Pain Clinical Research Center, Department of Neurology (J.D. Berry and Dr. Petersen), University of California, San Francisco; and Northwestern University Feinberg School of Medicine (J.D. Berry), Chicago, IL.


* To whom correspondence should be addressed. E-mail: klp{at}itsa.ucsf.edu.

Abstract-- This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster. Pain severity decreased by 66% with gabapentin compared to 33% with placebo. Reductions in allodynia area and severity, and overall pain relief, were also greater with gabapentin.




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