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Published online before print September 7, 2005, doi:10.1212/01.wnl.0000176988.87336.ff)
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Received March 31, 2005
Accepted June 22, 2005

Evaluation of adverse effects in intracarotid propofol injection for Wada test

N. Mikuni MD, PhD*, M. Takayama MD, T. Satow MD, PhD, S. Yamada MD, PhD, N. Hayashi MD, N. Nishida MD, J. Taki MD, R. Enatsu MD, A. Ikeda MD, PhD, S. Miyamoto MD, PhD, and N. Hashimoto MD, PhD

From the Departments of Neurosurgery (Drs. Mikuni, Takayama, Satow, Yamada, Hayashi, Nishida, Taki, Enatsu, Miyamoto, and Hashimoto) and Neurology (Ikeda), Kyoto University Graduate School of Medicine, Kyoto, Japan.


* To whom correspondence should be addressed. E-mail: mikunin{at}kuhp.kyoto-u.ac.jp.

Abstract-- The authors evaluated adverse effects of intracarotid propofol injection during a Wada test and their risk factors in 58 patients. Nineteen patients had an adverse effect, mostly in patients receiving more than 10 mg. For patients older than age 55 years or those requiring an injection dose greater than 20 mg to produce hemiplegia, propofol should be injected slowly and patients monitored for excitatory movements.




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