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Published online before print October 19, 2005, doi:10.1212/01.wnl.0000187889.17253.b1)
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Volume 65, Number 12, December 27, 2005
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Received February 24, 2005
Accepted August 2, 2005

Diagnosis and management of dementia with Lewy bodies. Third report of the DLB consortium

I. G. McKeith MD, FMedSci*, D. W. Dickson MD, J. Lowe DM, M. Emre MD, J. T. O’Brien DM, H. Feldman MDCM, J. Cummings MD, J. E. Duda MD, C. Lippa MD, E. K. Perry DSc, D. Aarsland MD, H. Arai MD, C. G. Ballard MD, B. Boeve MD, D. J. Burn FRCP, D. Costa MD, T. Del Ser MD, PhD, B. Dubois MD, D. Galasko MD, S. Gauthier MD, FRCPC, C. G. Goetz MD, E. Gomez-Tortosa MD, PhD, G. Halliday PhD, L. A. Hansen MD, J. Hardy PhD, T. Iwatsubo MD, R. N. Kalaria FRCPath, D. Kaufer MD, R. A. Kenny MD, A. Korczyn MD, K. Kosako MD, V. M.-Y. Lee PhD, MBA, A. Lees MD, I. Litvan MD, E. Londos MD, PhD, O. L. Lopez MD, S. Minoshima MD, PhD, Y. Mizuno MD, J. A. Molina MD, E. B. Mukaetove-Ladinska MD, PhD, F. Pasquier MD, PhD, R. H. Perry DSc, J. B. Schulz MD, J. Q. Trojanowski MD, PhD, M. Yamada MD, PhD, for the Consortium on DLB

From the Institute for Ageing and Health (Drs. McKeith, O’Brien, E.K. Perry, Burn, Kalaria, Kenny, Mukaetova-Ladinska, and R.H. Perry), University of Newcastle upon Tyne, UK; Department of Neuropathology (Dr. Dickson), Mayo Clinic Jacksonville, FL; Division of Pathology (Dr. Lowe), School of Molecular Medical Sciences, University of Nottingham, UK; Department of Neurology (Dr. Emre), Istanbul University, Istanbul Faculty of Medicine, Turkey; UBC Division of Neurology (Dr. Feldman), University of British Columbia, Vancouver, Canada; Department of Neurology (Dr. Cummings), UCLA Medical School Alzheimer’s Disease Center, Los Angeles, CA; Parkinson’s Disease Research, Education and Clinical Center (Dr. Duda), Philadelphia VAMC, PA; Memory Disorders Program (Dr. Lippa), Drexel University School of Medicine, Philadelphia, PA; Section of Geriatric Psychiatry (Dr. Aarsland), Stavanger University Hospital, Norway; Department of Geriatric & Respiratory Medicine (Dr. Arai), Tohoku University School of Medicine, Miyagi, Japan; Wolfson Centre for Age-Related Diseases (Dr. Ballard), London, UK; Department of Neurology (Dr. Boeve), Mayo Clinic, Rochester, MN; Institute of Nuclear Medicine (Dr. Costa), HPP Medicina Molecular, SA, Porto, Portugal; Section of Neurology (Dr. del Ser), Hospital Severo Ochoa, Madrid, Spain; Hopital La Salpêtrière (Dr. Dubois), Paris, France; Depts. of Neuroscience (Dr. Galasko) and Pathology (Dr. Hansen), University of California San Diego, La Jolla; MCSA Alzheimer’s Disease Research Unit (Dr. Gauthier), McGill Centre for Studies in Aging, Quebec, Canada; Department of Neurological Sciences (Dr. Goetz), Rush University Medical Center, Chicago, IL; Fundación Jiménez Diaz (Dr. Gómez-Tortosa), Servicio de Neurología, Madrid, Spain; Prince of Wales Medical Research Institute (Dr. Halliday), Sydney, Australia; Laboratory of Neurogenetics (Dr. Hardy), National Institute on Aging, Bethesda, MD; Department of Neuropathology & Neuroscience (Dr. Iwatsubo), University of Tokyo, Japan; Dept. of Neurology CB 7025 (Dr. Kaufer), University of North Carolina School of Medicine, Chapel Hill; Department of Neurology (Dr. Korczyn), Tel-Aviv University, Israel; Department of Psychiatry (Dr. Kosaka), Fukushimera Hospital, Toyohashi, Japan; Center for Neurodegenerative Disease Research (Drs. Lee and Trojanowski), University of Pennsylvania School of Medicine, Philadelphia; Reta Lila Weston Institute of Neurological Studies (Dr. Lees), Royal Free & UCL Medical School, London, UK; Department of Neurology (Dr. Litvan), Movement Disorder Program, University of Louisville School of Medicine, KY; Department of Clinical Sciences (Dr. Londos), University Hospital, Malmoe, Sweden; Neuropsychology Research Program (Dr. Lopez), University of Pittsburgh Medical College, PA; Department of Radiology (Dr. Minoshima), University of Washington, Seattle; Department of Neurology (Dr. Mizuno), Juntendo University School of Medicine, Tokyo, Japan; Servicio de Neurologia (Dr. Molina), Hospital 12 de Octubre, Madrid, Spain; Clinique Neurologique (Dr. Pasquier), Centre Hospitalier et Universitaire, Lille, France; Department of Neurodegeneration and Restorative Research Center of Neurological Medicine (Dr. Schulz), University of Göttingen, Germany; and Department of Neurology & Neurobiology of Ageing (Dr. Yamada), Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.


From the Institute for Ageing and Health (Drs. McKeith, O’Brien, E.K. Perry, Burn, Kalaria, Kenny, Mukaetova-Ladinska, and R.H. Perry), University of Newcastle upon Tyne, UK; Department of Neuropathology (Dr. Dickson), Mayo Clinic Jacksonville, FL; Division of Pathology (Dr. Lowe), School of Molecular Medical Sciences, University of Nottingham, UK; Department of Neurology (Dr. Emre), Istanbul University, Istanbul Faculty of Medicine, Turkey; UBC Division of Neurology (Dr. Feldman), University of British Columbia, Vancouver, Canada; Department of Neurology (Dr. Cummings), UCLA Medical School Alzheimer’s Disease Center, Los Angeles, CA; Parkinson’s Disease Research, Education and Clinical Center (Dr. Duda), Philadelphia VAMC, PA; Memory Disorders Program (Dr. Lippa), Drexel University School of Medicine, Philadelphia, PA; Section of Geriatric Psychiatry (Dr. Aarsland), Stavanger University Hospital, Norway; Department of Geriatric & Respiratory Medicine (Dr. Arai), Tohoku University School of Medicine, Miyagi, Japan; Wolfson Centre for Age-Related Diseases (Dr. Ballard), London, UK; Department of Neurology (Dr. Boeve), Mayo Clinic, Rochester, MN; Institute of Nuclear Medicine (Dr. Costa), HPP Medicina Molecular, SA, Porto, Portugal; Section of Neurology (Dr. del Ser), Hospital Severo Ochoa, Madrid, Spain; Hopital La Salpêtrière (Dr. Dubois), Paris, France; Depts. of Neuroscience (Dr. Galasko) and Pathology (Dr. Hansen), University of California San Diego, La Jolla; MCSA Alzheimer’s Disease Research Unit (Dr. Gauthier), McGill Centre for Studies in Aging, Quebec, Canada; Department of Neurological Sciences (Dr. Goetz), Rush University Medical Center, Chicago, IL; Fundación Jiménez Diaz (Dr. Gómez-Tortosa), Servicio de Neurología, Madrid, Spain; Prince of Wales Medical Research Institute (Dr. Halliday), Sydney, Australia; Laboratory of Neurogenetics (Dr. Hardy), National Institute on Aging, Bethesda, MD; Department of Neuropathology & Neuroscience (Dr. Iwatsubo), University of Tokyo, Japan; Dept. of Neurology CB 7025 (Dr. Kaufer), University of North Carolina School of Medicine, Chapel Hill; Department of Neurology (Dr. Korczyn), Tel-Aviv University, Israel; Department of Psychiatry (Dr. Kosaka), Fukushimera Hospital, Toyohashi, Japan; Center for Neurodegenerative Disease Research (Drs. Lee and Trojanowski), University of Pennsylvania School of Medicine, Philadelphia; Reta Lila Weston Institute of Neurological Studies (Dr. Lees), Royal Free & UCL Medical School, London, UK; Department of Neurology (Dr. Litvan), Movement Disorder Program, University of Louisville School of Medicine, KY; Department of Clinical Sciences (Dr. Londos), University Hospital, Malmoe, Sweden; Neuropsychology Research Program (Dr. Lopez), University of Pittsburgh Medical College, PA; Department of Radiology (Dr. Minoshima), University of Washington, Seattle; Department of Neurology (Dr. Mizuno), Juntendo University School of Medicine, Tokyo, Japan; Servicio de Neurologia (Dr. Molina), Hospital 12 de Octubre, Madrid, Spain; Clinique Neurologique (Dr. Pasquier), Centre Hospitalier et Universitaire, Lille, France; Department of Neurodegeneration and Restorative Research Center of Neurological Medicine (Dr. Schulz), University of Göttingen, Germany; and Department of Neurology & Neurobiology of Ageing (Dr. Yamada), Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.


* To whom correspondence should be addressed. E-mail: i.g.mckeith{at}ncl.ac.uk.

Abstract-- The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic weighting as features suggestive of a DLB diagnosis. The 1-year rule distinguishing between DLB and Parkinson disease with dementia may be difficult to apply in clinical settings and in such cases the term most appropriate to each individual patient should be used. Generic terms such as Lewy body (LB) disease are often helpful. The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count. The new criteria take into account both Lewy-related and Alzheimer disease (AD)-type pathology to allocate a probability that these are associated with the clinical DLB syndrome. Finally, the authors suggest patient management guidelines including the need for accurate diagnosis, a target symptom approach, and use of appropriate outcome measures. There is limited evidence about specific interventions but available data suggest only a partial response of motor symptoms to levodopa: severe sensitivity to typical and atypical antipsychotics in ~50%, and improvements in attention, visual hallucinations, and sleep disorders with cholinesterase inhibitors.




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D. W. Dickson, H. Fujishiro, D.C. Weisman, M . Cho, C. Taylor, A. Adame, and L.A. Hansen
IN DEMENTIA WITH LEWY BODIES, BRAAK STAGE DETERMINES PHENOTYPE, NOT LEWY BODY DISTRIBUTION
Neurology, May 27, 2008; 70(22): 2087 - 2089.
[Full Text] [PDF]


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NeurologyHome page
H. Braak and K. Del Tredici
Invited Article: Nervous system pathology in sporadic Parkinson disease
Neurology, May 13, 2008; 70(20): 1916 - 1925.
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J. Neuropsychiatry Clin. Neurosi.Home page
S. Wiederkehr, M. Simard, C. Fortin, and R. van Reekum
Comparability of the Clinical Diagnostic Criteria for Vascular Dementia: A Critical Review. Part I
J Neuropsychiatry Clin Neurosci, May 1, 2008; 20(2): 150 - 161.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
P. Piscopo, G. Marcon, M. R. Piras, A. Crestini, L. M. Campeggi, E. Deiana, R. Cherchi, F. Tanda, A. Deplano, N. Vanacore, et al.
A novel PSEN2 mutation associated with a peculiar phenotype
Neurology, April 22, 2008; 70(17): 1549 - 1554.
[Abstract] [Full Text] [PDF]


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J. Neurol. Neurosurg. PsychiatryHome page
G Roks, E S C Korf, W M van der Flier, P Scheltens, and C J Stam
The use of EEG in the diagnosis of dementia with Lewy bodies
J. Neurol. Neurosurg. Psychiatry, April 1, 2008; 79(4): 377 - 380.
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Arch NeurolHome page
T. Ikeuchi, A. Kakita, A. Shiga, K. Kasuga, H. Kaneko, C.-F. Tan, J. Idezuka, K. Wakabayashi, O. Onodera, T. Iwatsubo, et al.
Patients Homozygous and Heterozygous for SNCA Duplication in a Family With Parkinsonism and Dementia
Arch Neurol, April 1, 2008; 65(4): 514 - 519.
[Abstract] [Full Text] [PDF]


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CMAJHome page
H. H. Feldman MD, C. Jacova PhD, A. Robillard MD, A. Garcia MD PhD, T. Chow MD, M. Borrie MB ChB, H. M. Schipper MD PhD, M. Blair BSc, A. Kertesz MD, and H. Chertkow MD
Diagnosis and treatment of dementia: 2. Diagnosis
Can. Med. Assoc. J., March 25, 2008; 178(7): 825 - 836.
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NeurologyHome page
J. Zaccai, C. Brayne, I. McKeith, F. Matthews, P. G. Ince, and On behalf of the MRC Cognitive Function, Ageing Ne
Patterns and stages of {alpha}-synucleinopathy: Relevance in a population-based cohort
Neurology, March 25, 2008; 70(13): 1042 - 1048.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
K. Kawahara, M. Hashimoto, P. Bar-On, G. J. Ho, L. Crews, H. Mizuno, E. Rockenstein, S. Z. Imam, and E. Masliah
{alpha}-Synuclein Aggregates Interfere with Parkin Solubility and Distribution: ROLE IN THE PATHOGENESIS OF PARKINSON DISEASE
J. Biol. Chem., March 14, 2008; 283(11): 6979 - 6987.
[Abstract] [Full Text] [PDF]


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Arch NeurolHome page
I. F. Mata, A. Samii, S. H. Schneer, J. W. Roberts, A. Griffith, B. C. Leis, G. D. Schellenberg, E. Sidransky, T. D. Bird, J. B. Leverenz, et al.
Glucocerebrosidase Gene Mutations: A Risk Factor for Lewy Body Disorders
Arch Neurol, March 1, 2008; 65(3): 379 - 382.
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BrainHome page
L. Bonanni, A. Thomas, P. Tiraboschi, B. Perfetti, S. Varanese, and M. Onofrj
EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up
Brain, March 1, 2008; 131(3): 690 - 705.
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NeurologyHome page
J. L. Holton, S. A. Schneider, T. Ganesharajah, S. Gandhi, C. Strand, P. Shashidharan, J. Barreto, N. W. Wood, A. J. Lees, K. P. Bhatia, et al.
Neuropathology of primary adult-onset dystonia
Neurology, February 26, 2008; 70(9): 695 - 699.
[Abstract] [Full Text] [PDF]


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J. Neuropsychiatry Clin. Neurosi.Home page
A. Carota, N. Mishra, M. Allaoua, and J. Ghika
A Squint of Brain: A Capgras Syndrome Variant
J Neuropsychiatry Clin Neurosci, February 1, 2008; 20(1): 109 - 110.
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NeurologyHome page
A. M. Schmeichel, L. C. Buchhalter, P. A. Low, J. E. Parisi, B. W. Boeve, P. Sandroni, and E. E. Benarroch
Mesopontine cholinergic neuron involvement in Lewy body dementia and multiple system atrophy
Neurology, January 29, 2008; 70(5): 368 - 373.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
K. A. Jellinger
IN DEMENTIA WITH LEWY BODIES, BRAAK STAGE DETERMINES PHENOTYPE, NOT LEWY BODY DISTRIBUTION
Neurology, January 29, 2008; 70(5): 407 - 408.
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NeurologyHome page
G. N. Ransmayr, S. Holliger, K. Schletterer, H. Heidler, M. Deibl, W. Poewe, H. Madersbacher, and G. Kiss
Lower urinary tract symptoms in dementia with Lewy bodies, Parkinson disease, and Alzheimer disease
Neurology, January 22, 2008; 70(4): 299 - 303.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
T. Obi, K. Nishioka, O. A. Ross, T. Terada, K. Yamazaki, A. Sugiura, M. Takanashi, K. Mizoguchi, H. Mori, Y. Mizuno, et al.
CLINICOPATHOLOGIC STUDY OF A SNCA GENE DUPLICATION PATIENT WITH PARKINSON DISEASE AND DEMENTIA
Neurology, January 15, 2008; 70(3): 238 - 241.
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Am. J. Neuroradiol.Home page
D. Dormont, D.J. Seidenwurm, and for the Expert Panel on Neurologic Imaging
Dementia and Movement Disorders
AJNR Am. J. Neuroradiol., January 1, 2008; 29(1): 204 - 206.
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AM J ALZHEIMERS DIS OTHER DEMENHome page
G.D. Rabinovici, W.W. Seeley, E.J. Kim, M.L. Gorno-Tempini, K. Rascovsky, T.A. Pagliaro, S.C. Allison, C. Halabi, J.H. Kramer, J.K. Johnson, et al.
Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration
American Journal of Alzheimer's Disease and Other Dementias, January 1, 2008; 22(6): 474 - 488.
[Abstract] [PDF]


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NeurologyHome page
J. A. Schneider, Z. Arvanitakis, W. Bang, and D. A. Bennett
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Neurology, December 11, 2007; 69(24): 2197 - 2204.
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J Geriatr Psychiatry NeurolHome page
J. A. Levy and G. J. Chelune
Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease
J Geriatr Psychiatry Neurol, December 1, 2007; 20(4): 227 - 238.
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Arch NeurolHome page
K. A. Josephs
Capgras Syndrome and Its Relationship to Neurodegenerative Disease
Arch Neurol, December 1, 2007; 64(12): 1762 - 1766.
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J T O'BRIEN
Role of imaging techniques in the diagnosis of dementia
Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S71 - S77.
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Br. J. Radiol.Home page
S L PIMLOTT and K P EBMEIER
SPECT imaging in dementia
Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S153 - S159.
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J. Neurosci.Home page
H. Kaneko, A. Kakita, K. Kasuga, H. Nozaki, A. Ishikawa, A. Miyashita, R. Kuwano, G. Ito, T. Iwatsubo, H. Takahashi, et al.
Enhanced Accumulation of Phosphorylated {alpha}-Synuclein and Elevated -Amyloid 42/40 Ratio Caused by Expression of the Presenilin-1 {Delta}T440 Mutant Associated with Familial Lewy Body Disease and Variant Alzheimer's Disease
J. Neurosci., November 28, 2007; 27(48): 13092 - 13097.
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NeurologyHome page
M. Vendette, J. -F. Gagnon, A. Decary, J. Massicotte-Marquez, R. B. Postuma, J. Doyon, M. Panisset, and J. Montplaisir
REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia
Neurology, November 6, 2007; 69(19): 1843 - 1849.
[Abstract] [Full Text] [PDF]


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DTBHome page
How safe are antipsychotics in dementia?
DTB, November 1, 2007; 45(11): 81 - 85.
[Abstract] [Full Text] [PDF]


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J. Neurol. Neurosurg. PsychiatryHome page
Z. Walker, E. Jaros, R. W H Walker, L. Lee, D. C Costa, G. Livingston, P. G Ince, R. Perry, I. McKeith, and C. L E Katona
Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy
J. Neurol. Neurosurg. Psychiatry, November 1, 2007; 78(11): 1176 - 1181.
[Abstract] [Full Text] [PDF]


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PNHome page
I McKeith
Dementia with Lewy bodies and Parkinson's disease with dementia: where two worlds collide
Practical Neurology, November 1, 2007; 7(6): 374 - 382.
[Abstract] [Full Text] [PDF]


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BrainHome page
B. F. Boeve, M. H. Silber, C. B. Saper, T. J. Ferman, D. W. Dickson, J. E. Parisi, E. E. Benarroch, J. E. Ahlskog, G. E. Smith, R. C. Caselli, et al.
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
Brain, November 1, 2007; 130(11): 2770 - 2788.
[Abstract] [Full Text] [PDF]


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NeurologyHome page
H. Oka, M. Yoshioka, M. Morita, K. Onouchi, M. Suzuki, Y. Ito, T. Hirai, S. Mochio, and K. Inoue
Reduced cardiac 123I-MIBG uptake reflects cardiac sympathetic dysfunction in Lewy body disease
Neurology, October 2, 2007; 69(14): 1460 - 1465.
[Abstract] [Full Text] [PDF]


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Am. J. PsychiatryHome page
D. Weintraub and H. I. Hurtig
Presentation and Management of Psychosis in Parkinson's Disease and Dementia With Lewy Bodies
Am J Psychiatry, October 1, 2007; 164(10): 1491 - 1498.
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J. Neurol. Neurosurg. PsychiatryHome page
K. L Brickell, J. B Leverenz, E. J Steinbart, M. Rumbaugh, G. D Schellenberg, D. Nochlin, T. H Lampe, I. E Holm, V. V. Deerlin, W. Yuan, et al.
Clinicopathological concordance and discordance in three monozygotic twin pairs with familial Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1050 - 1055.
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Arch NeurolHome page
W. A. Rocca, J. H. Bower, J. E. Ahlskog, A. Elbaz, B. R. Grossardt, S. K. McDonnell, D. J. Schaid, and D. M. Maraganore
Risk of Cognitive Impairment or Dementia in Relatives of Patients With Parkinson Disease
Arch Neurol, October 1, 2007; 64(10): 1458 - 1464.
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NeurologyHome page
C. F. Lippa, B. F. Boeve, J. E. Parisi, and B. M. Keegan
A 75-year-old man with cognitive impairment and gait changes
Neurology, September 11, 2007; 69(11): 1183 - 1189.
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AM J ALZHEIMERS DIS OTHER DEMENHome page
M. Andersson, E. H. Wiig, L. Minthon, and E. Londos
A Quick Test for Cognitive Speed: A Measure of Cognitive Speed in Dementia With Lewy Bodies
American Journal of Alzheimer's Disease and Other Dementias, September 1, 2007; 22(4): 313 - 318.
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BrainHome page
V. Bogaerts, S. Engelborghs, S. Kumar-Singh, D. Goossens, B. Pickut, J. van der Zee, K. Sleegers, K. Peeters, J.-J. Martin, J. Del-Favero, et al.
A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder
Brain, September 1, 2007; 130(9): 2277 - 2291.
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NeurologyHome page
K. Seppi and O. Rascol
Dementia with Lewy bodies and Parkinson disease with dementia: Can MRI make the difference?
Neurology, August 21, 2007; 69(8): 717 - 718.
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NeurologyHome page
M. K. Beyer, J. P. Larsen, and D. Aarsland
Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies
Neurology, August 21, 2007; 69(8): 747 - 754.
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JNMHome page
H. Matsuda
Role of Neuroimaging in Alzheimer's Disease, with Emphasis on Brain Perfusion SPECT
J. Nucl. Med., August 1, 2007; 48(8): 1289 - 1300.
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NeurologyHome page
D. Weisman, M. Cho, C. Taylor, A. Adame, L. J. Thal, and L. A. Hansen
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
Neurology, July 24, 2007; 69(4): 356 - 359.
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J. Neurol. Neurosurg. PsychiatryHome page
K Mondon, A Gochard, A Marque, A Armand, D Beauchamp, C Prunier, D Jacobi, B de Toffol, A Autret, V Camus, et al.
Visual recognition memory differentiates dementia with Lewy bodies and Parkinson's disease dementia
J. Neurol. Neurosurg. Psychiatry, July 1, 2007; 78(7): 738 - 741.
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Am. J. Pathol.Home page
N. J. Cairns, M. Neumann, E. H. Bigio, I. E. Holm, D. Troost, K. J. Hatanpaa, C. Foong, C. L. White III, J. A. Schneider, H. A. Kretzschmar, et al.
TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions
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S. Amici, S. M. Brambati, D. P. Wilkins, J. Ogar, N. L. Dronkers, B. L. Miller, and M. L. Gorno-Tempini
Anatomical Correlates of Sentence Comprehension and Verbal Working Memory in Neurodegenerative Disease
J. Neurosci., June 6, 2007; 27(23): 6282 - 6290.
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NeurologyHome page
A. Minguez-Castellanos, C. E. Chamorro, F. Escamilla-Sevilla, A. Ortega-Moreno, A. C. Rebollo, M. Gomez-Rio, A. Concha, and D. G. Munoz
Do {alpha}-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: A cohort study
Neurology, June 5, 2007; 68(23): 2012 - 2018.
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Correspondence:

Read all Correspondence

Diagnosis and management of dementia with Lewy bodies. Third report of the DLB consortium
Laura Bonanni, et al.
Neurology Online, 22 Dec 2005 [Full text]
Reply from the Authors
Ian G. McKeith
Neurology Online, 22 Dec 2005 [Full text]



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