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Published online before print November 2, 2005, doi:10.1212/01.wnl.0000188670.38576.bd)
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Received June 27, 2005
Accepted September 22, 2005

A single-blind, open-label trial of sodium oxybate for myoclonus and essential tremor

S. J. Frucht MD*, W. C. Houghton MD, Y. Bordelon MD, PhD, P. E. Greene MD, and E. D. Louis MD, MS

From the Columbia University Medical Center (Drs. Frucht, Greene, and Louis), New York, Jazz Pharmaceuticals (Dr. Houghton), Palo Alto, CA, and University of California Los Angeles Medical Center (Dr. Bordelon), Los Angeles.


* To whom correspondence should be addressed. E-mail: sf216{at}columbia.edu.

Abstract-- The authors performed an open-label, rater-blinded, add-on study of sodium oxybate in 20 patients with ethanol-responsive myoclonus or essential tremor. Blinded ratings of videotaped examinations showed improvements in myoclonus at rest, stimulus-sensitive myoclonus, action myoclonus, functional performance, and postural and kinetic tremor. Tolerability was acceptable, and more than half of the patients chose to continue treatment after the trial. Double-blind placebo-controlled studies in these disorders are warranted.




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