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From the Departments of Neurology (Drs. Kuwabara, Misawa, Kanai, Kikkawa, and Hattori) and Hematology (Drs. Nishimura Nakaseko, and Cho), Chiba University School of Medicine, Japan.
* To whom correspondence should be addressed. E-mail: kuwabara-s{at}faculty.chiba-u.jp.
Abstract-- Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.
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