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-amyloid precursor protein in intracellular compartments
From the Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL.
* To whom correspondence should be addressed. E-mail: gopal{at}uchicago.edu.
Abstract--Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations in the past two decades, since the identification of A
as the principal component of brain senile plaques and the cloning of APP cDNA. Tremendous progress has been made in the recent past toward the characterization of - and 
-secretases. Here, we review the salient features of Alzheimer disease amyloidogenesis, and discuss the current knowledge on APP trafficking and amyloidogenic processing of APP in intracellular membrane compartments and microdomains.
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