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Published online before print December 16, 2005, doi:10.1212/01.wnl.0000192107.17175.39)
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Amyloidogenic processing of {beta}-amyloid precursor protein in intracellular compartments

Kulandaivelu S. Vetrivel PhD and Gopal Thinakaran PhD*

From the Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL.


* To whom correspondence should be addressed. E-mail: gopal{at}uchicago.edu.

Abstract--Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations in the past two decades, since the identification of A{beta} as the principal component of brain senile plaques and the cloning of APP cDNA. Tremendous progress has been made in the recent past toward the characterization of {beta}- and {gamma}-secretases. Here, we review the salient features of Alzheimer disease amyloidogenesis, and discuss the current knowledge on APP trafficking and amyloidogenic processing of APP in intracellular membrane compartments and microdomains.




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