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Published online before print March 15, 2006, doi:10.1212/01.wnl.0000206364.19772.39)
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 Volume 66, Number 10, May 23, 2006
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Received July 24, 2005
Accepted December 1, 2005

Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy

D. M. Andrade MD, MSc, D. Zumsteg MD, C. Hamani MD, M. Hodaie MD, MSc, FRCSC, S. Sarkissian PhD, A. M. Lozano MD, PhD, FRCSC, and R. A. Wennberg MD, MSc, FRCPC*

From Divisions of Neurology (D.M.A., D.Z., S.S., R.A.W.) and Neurosurgery (C.H., M.H., A.M.L.), Krembil Neuroscience Centre, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.


* To whom correspondence should be addressed. E-mail: r.wennberg{at}utoronto.ca.

Abstract-- The authors describe long-term follow-up (mean, 5 years) in patients with anterior (AN) (n = 6) or centromedian (n = 2) thalamic deep brain stimulation (DBS) for epilepsy. Five patients (all AN) had ≥50% seizure reduction, although benefit was delayed in two until years 5 to 6, after changes in antiepileptic drugs. DBS electrode implantation in AN patients was followed by seizure reduction 1 to 3 months before active stimulation, raising the possibility of a beneficial microthalamotomy effect.




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