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Published online before print April 19, 2006, doi:10.1212/01.wnl.0000218215.43328.88)
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 Volume 67, Number 3, August 8, 2006
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Received July 6, 2005
Accepted March 6, 2006

Identification of an oculomotor biomarker of preclinical Huntington disease

C. V.P. Golding PhD*, C. Danchaivijitr MRCP, T. L. Hodgson PhD, S. J. Tabrizi PhD, MRCP, and C. Kennard PhD, FRCP

From the Department of Clinical Neuroscience (C.V.P.G., C.D., C.K.), Faculty of Medicine, Imperial College; School of Psychology (T.L.H.), Exeter University; and Department of Neurodegenerative Disease (S.J.T.), Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.


* To whom correspondence should be addressed. E-mail: c.golding{at}imperial.ac.uk.

Abstract--The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington disease (HD). Initiation deficits of voluntary-guided, but not reflexive, saccades were characteristic of preclinical HD. Saccadic slowing and delayed reflexive saccades were demonstrated in clinical but not preclinical HD. Saccadic measures provide biomarkers of disease progression in both preclinical and early clinical stages of HD.




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